Review article
Antibiotic Resistance Mechanisms in Bacteria: Biochemical and Genetic Aspects
Senka Džidić
; Ruđer Bošković Institute, Department of Molecular Genetics, POB 180, HR-10002 Zagreb, Croatia
Jagoda Šušković
orcid.org/0000-0003-1711-316X
; Laboratory for Antibiotic, Enzyme, Probiotic and Starter Culture Technology, Faculty of Food Technology and Biotechnology, University of Zagreb, POB 625, HR-10001 Zagreb, Croatia
Blaženka Kos
; Laboratory for Antibiotic, Enzyme, Probiotic and Starter Culture Technology, Faculty of Food Technology and Biotechnology, University of Zagreb, POB 625, HR-10001 Zagreb, Croatia
Abstract
Since the discovery and subsequent widespread use of antibiotics, a variety of bacterial species of human and animal origin have developed numerous mechanisms that render bacteria resistant to some, and in certain cases to nearly all antibiotics. There are many important pathogens that are resistant to multiple antibiotic classes, and infections caused by multidrug resistant (MDR) organisms are limiting treatment options and compromising effective therapy. So the emergence of antibiotic-resistant pathogens in bacterial populations is a relevant field of study in molecular and evolutionary biology, and in medical practice. There are two main aspects to the biology of antimicrobial resistance. One is concerned with the development, acquisition and spread of the resistance gene itself. The other is the specific biochemical mechanism conveyed by this resistance gene. In this review we present some recent data on molecular mechanisms of antibiotic resistance.
Keywords
antibiotic resistance; antibiotic inactivation; target modification; membrane permeability changes; hypermutators; horizontal gene transfer
Hrčak ID:
22174
URI
Publication date:
14.3.2008.
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