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Review article

https://doi.org/10.2478/aiht-2020-71-3466

Carbamate group as structural motif in drugs: a review of carbamate derivatives used as therapeutic agents

Ana Matošević ; Institute for Medical Research and Occupational Health, Zagreb, Croatia
Anita Bosak orcid id orcid.org/0000-0003-0164-4994 ; Institute for Medical Research and Occupational Health, Zagreb, Croatia


Full text: english pdf 2.124 Kb

page 285-299

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Full text: croatian pdf 2.124 Kb

page 299-299

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Abstract

Due to their very good chemical and proteolytic stability, ability to penetrate cell membranes, and resemblance to a peptide bond, carbamate derivatives have received much attention in recent years and got an important role in modern drug discovery and medicinal chemistry. Today, carbamates make structural and/or functional part of many drugs and prodrugs approved and marketed for the treatment of various diseases such as cancer, epilepsy, hepatitis C, HIV infection, and Alzheimer’s disease. In drugs they can play a role in drug-target interaction or improve the biological activity of parent molecules. In prodrugs they are mainly used to delay first-pass metabolism and enhance the bioavailability and effectiveness of compounds. This brief review takes a look at the properties and use of carbamates in various fields of medicine and provides quick insights into the mechanisms of action for some of them.

Keywords

anticonvulsants; antiepileptics; cholinesterase inhibitors; neurodegenerative diseases; prodrugs; protease inhibitors

Hrčak ID:

248032

URI

https://hrcak.srce.hr/248032

Publication date:

23.12.2020.

Article data in other languages: croatian

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