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Acta clinica Croatica, Vol. 60. No. Supplement 1, 2021.

Original scientific paper

https://doi.org/10.20471/acc.2021.60.s1.03

Renal Function is Associated with Cataract Development in Patients with Type 2 Diabetes

Martina Tomić orcid id orcid.org/0000-0002-7535-3631 ; Department of Ophthalmology, Vuk Vrhovac University Clinic for Diabetes, Endocrinology and Metabolic Diseases, Merkur University Hospital
Romano Vrabec ; Department of Ophthalmology, Vuk Vrhovac University Clinic for Diabetes, Endocrinology and Metabolic Diseases, Merkur University Hospital
Spomenka Ljubić ; Department of Diabetes and Endocrinology, Vuk Vrhovac University Clinic for Diabetes, Endocrinology and Metabolic Diseases, Merkur University Hospital; Medical School, University of Zagreb
Tomislav Bulum orcid id orcid.org/0000-0003-4808-2968 ; Department of Diabetes and Endocrinology, Vuk Vrhovac University Clinic for Diabetes, Endocrinology and Metabolic Diseases, Merkur University Hospital; Medical School, University of Zagreb
Ingrid Prkačin orcid id orcid.org/0000-0002-5830-7131 ; Medical School, University of Zagreb; Department of Internal Medicine, Merkur University Hospital, Zagreb, Croatia
Dario Rahelić orcid id orcid.org/0000-0002-2901-0646 ; Department of Diabetes and Endocrinology, Vuk Vrhovac University Clinic for Diabetes, Endocrinology and Metabolic Diseases, Merkur University Hospital; Medical School, University of Zagreb

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Abstract

In this study, we investigated the impact of renal function, metabolic risk factors,
and duration of diabetes on cataract development in patients with type 2 diabetes (T2DM). This study
was cross-sectional and included 107 T2DM (67 male/40 female). Renal function was estimated with
a creatinine-based formula (eGFR) and with albumin/creatinine (A/C) ratio. Patients were divided
into three groups according to the LOCSIII classification: group 1 represents patients with clear
crystalline lens (n=16), group 2 represent patients with initial cataract (n=74), and group 3 represents
patients with immature cataract (n=17). Compared to group 1, group 3 had significantly longer diabetes
duration (17.12±6.38 vs. 10.81±4.09 years; p=0.004) and marginally higher HbA1c (7.11±1.41 vs.
6.38±0.83%; p=0.057). Diastolic blood pressure (DBP) was also significantly higher (90.94±15.41 vs.
76.47±6.32 mmHg; p=0.002) while eGFR was significantly lower (53 ± 18 vs. 72 ± 12 ml/min-
11.73m-2; p=0.014). In logistic regression analysis, DBP (AOR=1.06, 95%CI 1.00-1.12, p=0.039) and
eGFR (AOR=3.02, 95%CI 1.07-8.49, p=0.034) had a significant influence on cataract development
even after adjustment for well-known risk factors HbA1c and duration of diabetes. The results of the
study suggest a connection between renal function and cataract development in T2DM.

Keywords

Cataract; Type 2 diabetes; Blood pressure; Renal function

Hrčak ID:

260251

URI

https://hrcak.srce.hr/260251

Publication date:

1.1.2021.

Article data in other languages: croatian

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