Conference paper
ROLE OF COPPER AND KETAMINE IN MAJOR DEPRESSIVE DISORDER - AN UPDATE
Jakub Słupski
orcid.org/0000-0002-4579-0208
; Department of Psychiatry, Faculty of Medicine, Medical University of Gdansk, Poland
Anita Słupska
; Department of Psychiatry, Faculty of Medicine, Medical University of Gdansk, Poland
Łukasz P. Szałach
; Department of Psychiatry, Faculty of Medicine, Medical University of Gdansk, Poland
Adam Włodarczyk
; Department of Psychiatry, Faculty of Medicine, Medical University of Gdansk, Poland
Natalia Górska
; Department of Psychiatry, Faculty of Medicine, Medical University of Gdansk, Poland
Joanna Szarmach
; Department of Psychiatry, Faculty of Medicine, Medical University of Gdansk, Poland
Katarzyna Jakuszkowiak-Wojten
; Department of Psychiatry, Faculty of Medicine, Medical University of Gdansk, Poland
Maria Gałuszko-Węgielnik
; Department of Psychiatry, Faculty of Medicine, Medical University of Gdansk, Poland
Alina Wilkowska
; Department of Psychiatry, Faculty of Medicine, Medical University of Gdansk, Poland
Mariusz S. Wiglusz
; Department of Psychiatry, Faculty of Medicine, Medical University of Gdansk, Poland
Wiesław Jerzy Cubała
; Department of Psychiatry, Faculty of Medicine, Medical University of Gdansk, Poland
Abstract
Major depressive disorder is one of the most important psychiatric issues worldwide, with important prevalence of treatmentresistant
depression (TRD). Non-monoaminergic agents are currently in the spotlight. Objective was to explore for information
about mechanisms of action of ketamine, its connections with copper and possible importance for TRD treatment. There are at least
few possible pathways for ketamine action in depression in which copper and other divalent ions may show a vital role. There is urgent
need for more studies to gather information about correlation between ketamine, copper and antidepressive features of these agents.
Keywords
ketamine; copper; major depressive disorder; NMDA
Hrčak ID:
264162
URI
Publication date:
4.9.2019.
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