Reminescences
POSTOPERATIVE THROMBOCYTOSIS IN CLINICAL PRACTICE
ANA MILIČEVIĆ
; University of Zagreb, School of Medicine, Zagreb, Croatia
MATEA MILANOVIĆ
; University of Zagreb, School of Medicine, Zagreb, Croatia
INGA MANDAC SMOLJANOVIĆ
orcid.org/0000-0001-5234-9464
; University of Zagreb, School of Medicine, Zagreb; Merkur University Hospital, Department of Hematology, Zagreb, Croatia
Abstract
Thrombocytosis refers to a condition of elevated platelet count in peripheral blood. The normal platelet count ranges from 150x109/L to 450x109/L, and an elevated value is considered to be above 450x109/L. Regulation of platelet production is based on the production of thrombopoietin, a growth factor and stimulation of megakaryocytes, which in response to reduced platelet count is excreted from the liver, and to a lesser extent from the kidneys, and leads to bone marrow stimulation. In contrast, at elevated platelet counts, thrombopoietin production is blocked by feedback, and under normal conditions, the platelet to thrombopoietin ratio is inversely proportional. However, this process is infl uenced by a number of factors other than the platelet count itself. In conditions with infl ammatory events in the body, trauma, tumors, there may be increased production of thrombopoietin and secondary thrombocytosis. Due to similarities in the structure of erythropoietin and thrombopoietin, secondary thrombocytosis can often be found in people with anemia in response to decreased hemoglobin levels. Because of all the above, it is likely that thrombocytosis can have a number of causes, and their proper recognition is the basis for the treatment and control of this condition.
Keywords
thrombocytosis, thrombopoieti; , primary and secondary thrombocytosis; postoperative condition
Hrčak ID:
274020
URI
Publication date:
16.3.2022.
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