Original scientific paper
https://doi.org/10.20471/acc.2022.61.s3.1
Correlation of Expression of TGF- β and MMP2 between Prostatic Adenocarcinoma and Adjacent Unaffected Parenchyma
Silvija Mašić
; Ljudevit Jurak Clinical Department of Pathology and Cytology, Sestre milosrdnice University Hospital Center, Zagreb, Croatia; Department of Pathology, School of Medicine, University of Zagreb, Zagreb, Croatia
Jasna Bacalja
; Department of Pathology, Centrallasarettet Växjö, Växjö, Sweden
Majda Vučić
; Ljudevit Jurak Clinical Department of Pathology and Cytology, Sestre milosrdnice University Hospital Center, Zagreb, Croatia; Department of Pathology, School of Dental Medicine, University of Zagreb, Zagreb, Croatia
Hrvoje Čupić
; Ljudevit Jurak Clinical Department of Pathology and Cytology, Sestre milosrdnice University Hospital Center, Zagreb, Croatia; Department of Pathology, School of Dental Medicine, University of Zagreb, Zagreb, Croatia
Davor Tomas
; Ljudevit Jurak Clinical Department of Pathology and Cytology, Sestre milosrdnice University Hospital Center, Zagreb, Croatia; Scientific Group for Research on Epigenetic Biomarkers, School of Medicine, University of Zagreb, Zagreb, Croatia; Department of Pathology, School of Medicine, University of Zagreb, Zagreb, Croatia
Monika Ulamec
; Ljudevit Jurak Clinical Department of Pathology and Cytology, Sestre milosrdnice University Hospital Center, Zagreb, Croatia; Department of Pathology, School of Dental Medicine, University of Zagreb, Zagreb, Croatia; Scientific Group for Research on Epigenetic Biomarkers, School of Medicine, University of Zagreb, Zagreb, Croatia; Department of Pathology, School of Medicine, University of Zagreb, Zagreb, Croatia
Borislav Spajić
; Clinical Department of Urology, Sestre milosrdnice University Hospital Center, Zagreb, Croatia
Faruk Skenderi
; Faculty of Health Sciences, University of Sarajevo, Sarajevo, Bosnia and Herzegovina
Božo Krušlin
; Ljudevit Jurak Clinical Department of Pathology and Cytology, Sestre milosrdnice University Hospital Center, Zagreb, Croatia; Scientific Group for Research on Epigenetic Biomarkers, School of Medicine, University of Zagreb, Zagreb, Croatia
Abstract
In prostate adenocarcinoma, both tumorous stroma and epithelium have important
role in tumor progression. Transforming growth factor beta (TGF- β) is a promotor in advanced
stages of prostate cancer. Matrix Metalloproteinase 2 (MMP2), the endopeptidase that degrades extracellular
matrix is considered to be overexpressed in prostatic carcinoma related to its growth and
aggressiveness. Therefore, the aim was to analyze the expression of proteins TGF- β and MMP2 between
both epithelium and stroma of prostatic adenocarcinoma and adjacent unaffected parenchyma.
The intensity of TGF- β and MMP2 expression in epithelium, tumorous stroma and adjacent unaffected
parenchyma was analyzed in 62 specimens of prostatic adenocarcinoma by microarray-based
immunohistochemistry. TGF- β was more expressed in tumorous than in prostate stroma (p =0.000),
while no statistical significance in case of MMP2 (p = 0.097) was found. MMP2 was more expressed
in tumorous than in prostate epithelium (p =0.000), while no statistical significance in case of TGF- β
(p = 0.096) was observed. The study results indicate that both tumorous stroma and epithelium have
a role in tumor progression and support potential role of TGF- β and MMP2 in prostatic adenocarcinoma
progression.
Keywords
TGF- β; MMP2; Prostatic Adenocarcinoma; Unaffected Parenchyma
Hrčak ID:
286243
URI
Publication date:
1.10.2022.
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