Izvorni znanstveni članak
https://doi.org/10.20471/acc.2022.61.s3.1
Korelacija ekspresije TGF-β i MMP2 između adenokarcinoma prostate i okolnog nezahvaćenog parenhima
Silvija Mašić
; Ljudevit Jurak Clinical Department of Pathology and Cytology, Sestre milosrdnice University Hospital Center, Zagreb, Croatia; Department of Pathology, School of Medicine, University of Zagreb, Zagreb, Croatia
Jasna Bacalja
; Department of Pathology, Centrallasarettet Växjö, Växjö, Sweden
Majda Vučić
; Ljudevit Jurak Clinical Department of Pathology and Cytology, Sestre milosrdnice University Hospital Center, Zagreb, Croatia; Department of Pathology, School of Dental Medicine, University of Zagreb, Zagreb, Croatia
Hrvoje Čupić
; Ljudevit Jurak Clinical Department of Pathology and Cytology, Sestre milosrdnice University Hospital Center, Zagreb, Croatia; Department of Pathology, School of Dental Medicine, University of Zagreb, Zagreb, Croatia
Davor Tomas
; Ljudevit Jurak Clinical Department of Pathology and Cytology, Sestre milosrdnice University Hospital Center, Zagreb, Croatia; Scientific Group for Research on Epigenetic Biomarkers, School of Medicine, University of Zagreb, Zagreb, Croatia; Department of Pathology, School of Medicine, University of Zagreb, Zagreb, Croatia
Monika Ulamec
; Ljudevit Jurak Clinical Department of Pathology and Cytology, Sestre milosrdnice University Hospital Center, Zagreb, Croatia; Department of Pathology, School of Dental Medicine, University of Zagreb, Zagreb, Croatia; Scientific Group for Research on Epigenetic Biomarkers, School of Medicine, University of Zagreb, Zagreb, Croatia; Department of Pathology, School of Medicine, University of Zagreb, Zagreb, Croatia
Borislav Spajić
; Clinical Department of Urology, Sestre milosrdnice University Hospital Center, Zagreb, Croatia
Faruk Skenderi
; Faculty of Health Sciences, University of Sarajevo, Sarajevo, Bosnia and Herzegovina
Božo Krušlin
; Ljudevit Jurak Clinical Department of Pathology and Cytology, Sestre milosrdnice University Hospital Center, Zagreb, Croatia; Scientific Group for Research on Epigenetic Biomarkers, School of Medicine, University of Zagreb, Zagreb, Croatia
Sažetak
U progresiji karcinoma prostate tumorska stroma i epitel imaju važnu ulogu. Beta transformirajući faktor rasta (TGF-
β) djeluje kao promotor u uznapredovalom raku prostate, a matriks metaloproteinaza 2 (MMP2) kao endopeptidaza koja
razgrađuje izvanstanični matriks te je njezina aktivnost pojačano izražena te povezana s rastom i agresivnošću ovog tumora.
Stoga je cilj ovog istraživanja bio analizirati izraženost TGF- β u MMP2 između epitela i strome karcinoma prostate te
okolnog tumorom nezahvaćenog parenhima prostate. Intenzitet izraženosti TGF- β i MMP2 u tumorskom epitelu i stromi
te okolnom nezahvaćenom parenhimu je analiziran u 62 pacijenta s adenokarcinomom prostate metodom imunohistokemijske
analize na uzorcima microarray-a. TGF- β je bio izraženiji u tumorskoj nego u ne- tumorskoj stromi (p =0.000), dok u
slučaju izraženosti MMP2 nije pokazana statistička značajnost (p = 0.097). MMP2 je bila izraženija u tumorskom epitelu u
odnosu na ne- tumorski epitel (p =0.000), dok statistička značajnost u slučaju izraženosti TGF- β nije pokazana (p = 0.096).
Rezultati ovog istraživanja pokazuju da i tumorski epitel i stroma imaju ulogu u progresiji tumora i ukazuju na potencijalnu
ulogu TGF- β i MMP2 u progresiji adenokarcinoma prostate.
Ključne riječi
TGF- β; MMP2; adenokarcinom prostate; ne- tumorski parenhim
Hrčak ID:
286243
URI
Datum izdavanja:
1.10.2022.
Posjeta: 659 *