Review article
https://doi.org/10.15255/KUI.2022.027
Pharmaceutical Significance of the Stereoisomerisation Process
Lucija Hok
orcid.org/0000-0003-0731-1293
; Ruđer Bošković Institute, Division of Organic Chemistry and Biochemistry, Laboratory for the Computational Design and Synthesis of Functional Materials, Bijenička cesta 54, 10 000, Zagreb, Croatia
Davor Šakić
orcid.org/0000-0002-8871-6622
; University of Zagreb, Faculty of Pharmacy and Biochemistry, Department of Analytical Chemistry, Ul. Ante Kovačića 1, 10 000 Zagreb, Croatia
Valerije Vrček
orcid.org/0000-0003-1624-8126
; University of Zagreb, Faculty of Pharmacy and Biochemistry, Department of Organic Chemistry, Ul. Ante Kovačića 1, 10 000 Zagreb, Croatia
Robert Vianello
orcid.org/0000-0003-1779-4524
; Ruđer Bošković Institute, Division of Organic Chemistry and Biochemistry, Laboratory for the Computational Design and Synthesis of Functional Materials, Bijenička cesta 54, 10 000, Zagreb, Croatia
Abstract
Investigation of the stereoisomerisation process is of the utmost importance in pharmaceutical chemistry and biomedicine. Different isomers can exhibit significant differences when interacting with biological macromolecules, which may result in their modified pharmacokinetic and pharmacodynamic properties, thereby showing different therapeutic and undesirable effects. Although there are numerous examples illustrating the importance of stereochemistry, this article presents an overview of the most significant and representative cases in pharmacy.
Keywords
stereoisomers; configurational instability; pharmacological and pharmaceutical time scales; chiral drugs
Hrčak ID:
291082
URI
Publication date:
11.1.2023.
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