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CUMULATIVE PREGNANCY RATES AFTER FRESH AND FIRST SUBSEQUENT TRANSFER OF THAWED EMBRYOS: IS IT TIME TO CHANGE PRACTICE?
DARIA HAFNER
; Laboratory for Human Reproduction, Clinic of Obstetrics and Gynecology, Clinical Hospital Sveti Duh, Zagreb, Croatia
*
RENATO BAUMAN
; Merrion Fertility Clinic, Dublin 2, Ireland
SANJA CVRTILA
; Laboratory for Human Reproduction, Clinic of Obstetrics and Gynecology, Clinical Hospital Sveti Duh, Zagreb, Croatia
TATJANA PAVELIC TURUDIC
; Laboratory for Human Reproduction, Clinic of Obstetrics and Gynecology, Clinical Hospital Sveti Duh, Zagreb, Croatia
SANJA VUJISIC ZIVKOVIC
; BetaPlus Center for Reproductive Medicine, Zagreb, Croatia
* Corresponding author.
Abstract
The aim: was to clarify parameters that contribute to successful pregnancy outcomes from one oocyte retrieval cycle with the
least procedure steps. Methods: This retrospective study included 42 stimulated IVF cycles with fresh embryo transfers (fresh ET)
and the subsequent 42 frozen embryo transfer cycles (FET) performed between January 2012 and December 2015. Results: The observed clinical pregnancy rate of 21.4% in stimulated cycles with fresh embryo transfers was significantly lower compared with
the pregnancy rate of 52.4% in cycles with thawed embryo transfers (p=0.015) indicating impaired endometrium quality in stimulated IVF cycles. Most of the patients (78.6%) failed to achieve pregnancy after fresh ET, but more than half of them (57.6%) succeeded to achieve pregnancy after FET. The cumulative pregnancy rate after fresh ET and the first subsequent FET was 73.8% per initiated cycle. Conclusion: The results suggest that not only the presence of supernumerary good-quality blastocysts but
also a receptive endometrium is needed for a successful IVF outcome. Our findings suggest that ovarian stimulation protocol had
an impact on the pregnancy rate in the fresh cycle and that a better chance of conceiving was after FET. Thus, IVF outcomes can
be improved with a better embryo transfer strategy.
Keywords
freeze-all cycle; fresh embryo transfer; frozen-thawed embryo transfer
Hrčak ID:
310547
URI
Publication date:
22.11.2023.
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