Original scientific paper
https://doi.org/10.15255/KUI.2023.037
Correlation between Optical Characteristics of Orodispersible Films with Selected Process Parameters Supported by FTIR Analysis
Ognjenka Rahić
orcid.org/0000-0003-0183-1124
; University of Sarajevo, Faculty of Pharmacy, Department of Pharmaceutical Technology, Zmaja od Bosne 8, 71 000 Sarajevo, Bosnia and Herzegovina
*
Amina Tucak-Smajić
; University of Sarajevo, Faculty of Pharmacy, Department of Pharmaceutical Technology, Zmaja od Bosne 8, 71 000 Sarajevo, Bosnia and Herzegovina
Merima Šahinović
; University of Sarajevo, Faculty of Pharmacy, Department of Pharmaceutical Technology, Zmaja od Bosne 8, 71 000 Sarajevo, Bosnia and Herzegovina
Belma Imamović
orcid.org/0000-0002-2500-1419
; University of Sarajevo, Faculty of Pharmacy, Department of Drug Analysis, Zmaja od Bosne 8, 71 000 Sarajevo, Bosnia and Herzegovina
Lamija Hindija
; University of Sarajevo, Faculty of Pharmacy, Department of Pharmaceutical Technology, Zmaja od Bosne 8, 71 000 Sarajevo, Bosnia and Herzegovina
Jasmina Hadžiabdić
; University of Sarajevo, Faculty of Pharmacy, Department of Pharmaceutical Technology, Zmaja od Bosne 8, 71 000 Sarajevo, Bosnia and Herzegovina
Edina Vranić
; University of Sarajevo, Faculty of Pharmacy, Department of Pharmaceutical Technology, Zmaja od Bosne 8, 71 000 Sarajevo, Bosnia and Herzegovina
* Corresponding author.
Abstract
Paediatric and geriatric populations, as well as other special patient populations with swallowing problems, require patient-tailored dosage forms. One promising dosage form for these specific populations is orodispersible films.
When preparing orodispersible films using sodium carboxymethyl cellulose as the film-forming polymer and glycerine as the plasticizer, it is essential to determine the optimal mixing time and mixing speed of the casting solution to achieve the desired transparency/opacity of the orodispersible films. In this paper, the primary focus is on mixing time and mixing speed, and determining how these two parameters can influence optical characteristics. All tested parameters are supported by FTIR analysis. The obtained results show that either a mixing speed of 7000 rpm on a high-shear mixer for 15 min or a mixing speed of 9000 rpm for 5 min can produce films with optimal optical characteristics.
Keywords
orodisperisble films; sodium carboxymethyl cellulose; glycerine; optical characteristics; FTIR
Hrčak ID:
316818
URI
Publication date:
14.5.2024.
Visits: 43 *