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Medicina Fluminensis, Vol. 61 No. 4, 2025.

Review article

https://doi.org/10.21860/medflum2025_336640

Nuclear Medicine Imaging in Prostate Cancer: Current Evidence and Clinical Applications

Charlotte Caroline Fruböse ; Faculty of Medicine, University of Rijeka, Rijeka, Croatia
Neva Girotto ; Department of Radiological Diagnostics, Faculty of Health Studies, University of Rijeka, Rijeka, Croatia; Medikol Policlinics, PET/CT Centre Rijeka, Rijeka, Croatia
Maja Ilić Tomaš orcid id orcid.org/0000-0001-5863-9251 ; Faculty of Medicine, University of Rijeka, Rijeka, Croatia; Department of Nuclear Medicine, Clinical Hospital Center Rijeka, Rijeka, Croatia *
Dražen Huić ; Clinical Department of Nuclear Medicine and Radiation Protection, University Hospital Centre Zagreb, Zagreb, Croatia; School of Medicine, University of Zagreb, Zagreb, Croatia
Martina Ciglar Hlašć ; Clinical Department of Nuclear Medicine and Radiation Protection, University Hospital Centre Zagreb, Zagreb, Croatia
Dean Markić ; Faculty of Medicine, University of Rijeka, Rijeka, Croatia; Department of Urology, Clinical Hospital Center Rijeka, Rijeka, Croatia
Tatjana Bogović Crnčić ; Faculty of Medicine, University of Rijeka, Rijeka, Croatia; Department of Nuclear Medicine, Clinical Hospital Center Rijeka, Rijeka, Croatia

* Corresponding author.

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Abstract

Prostate cancer (PCa) is the most commonly diagnosed malignancy in men, and aleading cause of cancer-related death. Accurate imaging is essential for diagnosis, staging,and therapy planning. Prostate-specific membrane antigen (PSMA)-targeted radiotracersprovide superior sensitivity and specificity across clinical scenarios. In biochemicalrecurrence, PSMA positron emission tomography/computed tomography (PET/CT) offersthe highest detection rates, especially at low prostate-specific antigen (PSA) levels. Cholineand fluciclovine PET/CT remain valuable alternatives. Bone scintigraphy, fluoride PET/CT,and MRI contribute to skeletal staging. Molecular imaging has significantly advanced PCamanagement, enabling more precise diagnosis and treatment. This review summarizesrecent advances in PSMA-targeted nuclear imaging.

Keywords

nuclear medicine; prostate cancer; scintigraphy; theranostics

Hrčak ID:

336640

URI

https://hrcak.srce.hr/336640

Publication date:

1.12.2025.

Article data in other languages: croatian

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