Biochemia Medica, Vol. 19 No. 3, 2009.
Review article
Primjena biološke varijacije - pregledni članak
Carmen Ricós
; Analytical Quality Committee, Spanish Society of Clinical Biochemistry and Molecular Pathology (SEQC), Spain; Laboratory Department, University Hospital Vall d'Hebron, Barcelona, Spain
Carmen Perich
; Analytical Quality Committee, Spanish Society of Clinical Biochemistry and Molecular Pathology (SEQC), Spain; Laboratory Department, Primary Care Center Bon Pastor, Barcelona, Spain
Joana Minchinela
; Analytical Quality Committee, Spanish Society of Clinical Biochemistry and Molecular Pathology (SEQC), Spain; Laboratory Department, Primary Care Center Barcelonès Nord, Badalona, Spain
Virtudes Álvarez
; Analytical Quality Committee, Spanish Society of Clinical Biochemistry and Molecular Pathology (SEQC), Spain; Laboratory Department, Primary Care Center Hospitalet, Hospitalet, Spain
Margarita Simón
; Analytical Quality Committee, Spanish Society of Clinical Biochemistry and Molecular Pathology (SEQC), Spain; Laboratory Department, Hospital Anoia, Vilafranca del Penedès, Spain
Carmen Biosca
; Analytical Quality Committee, Spanish Society of Clinical Biochemistry and Molecular Pathology (SEQC), Spain; Laboratory Department, Hospital Germans Trías i Pujol, Badalona, Spain
Mariví Doménech
; Analytical Quality Committee, Spanish Society of Clinical Biochemistry and Molecular Pathology (SEQC), Spain; Laboratory Department, Primary Care Center Manso, Barcelona, Spain
Pilar Fernández
; Analytical Quality Committee, Spanish Society of Clinical Biochemistry and Molecular Pathology (SEQC), Spain; Biochemistry Department, Hospital La Paz, Madrid, Spain
Carlos-Víctor Jiménez
; Analytical Quality Committee, Spanish Society of Clinical Biochemistry and Molecular Pathology (SEQC), Spain; Laboratory Department, Primary Care Center Barcelonès Nord, Badalona, Spain
José Vicente Garcia-Lario
; Analytical Quality Committee, Spanish Society of Clinical Biochemistry and Molecular Pathology (SEQC), Spain; Laboratory Department, University Hospital Virgen de las Nieves, Granada, Spain
Fernando Cava
; Analytical Quality Committee, Spanish Society of Clinical Biochemistry and Molecular Pathology (SEQC), Spain; Laboratory Department, Hospital Alcorcón Foundation, Madrid, Spain
Abstract
Ovaj rad sadrži opsežan pregled sastavnica biološke varijacije (BV), tj. intraindividualne (nasumična fluktuacija analita oko osnovne vrijednosti svakog pojedinca) i interindividualne (ukupna varijacija od osnovnih vrijednosti različitih osoba) varijacije, zatim ukratko objašnjava procjenu veličine intraindividualne i interindividualne BV u zdravih i oboljelih ispitanika, podrobno obrađuje osam složenijih primjena procjena BV, te govori o zanimljivim detaljima koji izazivaju najviše rasprava.
Cilj rada je raspraviti kako pomoću današnje tehnologije doći do specifikacija kvalitete dobivenih na temelju BV u zdravih pojedinaca te u kojim se slučajevima koristiti podacima od oboljelih ispitanika.
Konačno, u radu se promiče daljnji razvoj primjene BV, poput upozoravanja liječnika o promjenama u bolesnikovu stanju.
Keywords
biološka varijacija; specifikacije kvalitete; referentna vrijednost promjene; delta provjera; laboratorijski nalaz
Hrčak ID:
40854
URI
Publication date:
24.9.2009.
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