Pregledni rad

Application of biological variation - a review

Carmen Ricós ; Analytical Quality Committee, Spanish Society of Clinical Biochemistry and Molecular Pathology (SEQC), Spain; Laboratory Department, University Hospital Vall d'Hebron, Barcelona, Spain
Carmen Perich ; Analytical Quality Committee, Spanish Society of Clinical Biochemistry and Molecular Pathology (SEQC), Spain; Laboratory Department, Primary Care Center Bon Pastor, Barcelona, Spain
Joana Minchinela ; Analytical Quality Committee, Spanish Society of Clinical Biochemistry and Molecular Pathology (SEQC), Spain; Laboratory Department, Primary Care Center Barcelonès Nord, Badalona, Spain
Virtudes Álvarez ; Analytical Quality Committee, Spanish Society of Clinical Biochemistry and Molecular Pathology (SEQC), Spain; Laboratory Department, Primary Care Center Hospitalet, Hospitalet, Spain
Margarita Simón ; Analytical Quality Committee, Spanish Society of Clinical Biochemistry and Molecular Pathology (SEQC), Spain; Laboratory Department, Hospital Anoia, Vilafranca del Penedès, Spain
Carmen Biosca ; Analytical Quality Committee, Spanish Society of Clinical Biochemistry and Molecular Pathology (SEQC), Spain; Laboratory Department, Hospital Germans Trías i Pujol, Badalona, Spain
Mariví Doménech ; Analytical Quality Committee, Spanish Society of Clinical Biochemistry and Molecular Pathology (SEQC), Spain; Laboratory Department, Primary Care Center Manso, Barcelona, Spain
Pilar Fernández ; Analytical Quality Committee, Spanish Society of Clinical Biochemistry and Molecular Pathology (SEQC), Spain; Biochemistry Department, Hospital La Paz, Madrid, Spain
Carlos-Víctor Jiménez ; Analytical Quality Committee, Spanish Society of Clinical Biochemistry and Molecular Pathology (SEQC), Spain; Laboratory Department, Primary Care Center Barcelonès Nord, Badalona, Spain
José Vicente Garcia-Lario ; Analytical Quality Committee, Spanish Society of Clinical Biochemistry and Molecular Pathology (SEQC), Spain; Laboratory Department, University Hospital Virgen de las Nieves, Granada, Spain
Fernando Cava ; Analytical Quality Committee, Spanish Society of Clinical Biochemistry and Molecular Pathology (SEQC), Spain; Laboratory Department, Hospital Alcorcón Foundation, Madrid, Spain

Sažetak

This paper introduces an extensive revision of the types of components of biological variation (BV), i.e. intraindividual (random fluctuation of analytes around the setting point of each individual) and interindividual (overall variation from the different person's setting point), briefly explains estimation of the magnitude of within- and between subject BV in healthy and non-healthy subjects, details the eight common applications of BV estimates and discusses the most debated points of interests.
The aim is to discuss how quality specifications derived from BV determined in healthy individuals are attainable with current technology and in what cases data from non-healthy subjects should be used.
Finally, the paper promotes further development of BV application, such as notifying doctors about changes in patient status.

Ključne riječi

biological variation; quality specifications; reference change value; delta check; laboratory report

Hrčak ID:

40854

URI

https://hrcak.srce.hr/40854

Datum izdavanja:

24.9.2009.

Podaci na drugim jezicima: hrvatski

Posjeta: 3.626 *