Pregledni rad
https://doi.org/10.2478/10004-1254-63-2012-2185
Dipeptidyl Peptidase IV in Inflammatory Bowel Diseases (DPP IV/CD26)
Lara Batičić Pučar
; Zavod za kemiju i biokemiju, Medicinski fakultet Sveučilišta u Rijeci, Rijeka, Hrvatska
Dijana Detel
; Zavod za kemiju i biokemiju, Medicinski fakultet Sveučilišta u Rijeci, Rijeka, Hrvatska
Jadranka Varljen
; Zavod za kemiju i biokemiju
Sažetak
Infl ammatory bowel diseases (Crohn’s disease, ulcerative colitis, undetermined colitis) are a group of chronic autoimmune inflammatory diseases distinguished by recurrent inflammation of various parts of the gastrointestinal (GI) system and presenting a significant public health problem. Despite large basic and clinical research, the aetiology of these diseases and the pathogenesis of inflammation itself remain elusive. Previous studies have confirmed a causal relationship between mediators of inflammatory response and molecules involved in the regulation of their biological activity, especially proteases. The aim of this review is to summarise earlier findings on different aspects of inflammatory bowel diseases, paying particular attention to the involvement of dipeptidyl peptidase IV (CD26 molecule, DPP IV/CD26) in the etiopathogenesis of inflammatory processes in the GI tract. Animal studies of colitis have significantly contributed to the understanding and treatment of these diseases, investigations of ulcerative colitis (DSS-colitis) and Crohn’s disease (TNBS-colitis) on the murine model in particular.
Ključne riječi
animal models of colitis; CD26 molecule; Crohn’s disease; DSS-colitis; TNBS-colitis; ulcerative colitis
Hrčak ID:
78649
URI
Datum izdavanja:
21.3.2012.
Posjeta: 2.091 *