Pregledni rad
Early diagnosis of rheumatoid arthritis
Đurđica BABIĆ-NAGLIĆ
; Klinika za reumatske bolesti i rehabilitaciju Klinički bolnički centar Zagreb, Kišpatićeva 12, Zagreb
Iva ŽAGAR
; Klinika za reumatske bolesti i rehabilitaciju Klinički bolnički centar Zagreb, Kišpatićeva 12, Zagreb
Sažetak
Rheumatoid arthritis (RA) is chronic joint disease which if untreated leads to permanent structural damage and disability. Early diagnosis and therapy are the main requests for good clinical practice. Early diagnosis tools include specific clinical assesment, serological, immunogenetic and radiological evaluation. Disease activity score is cornerstone in clinical assesment, rheumatoid factor and anti-cyclic
citrullinated peptide antibodies (anti-CCP) are very specific serological parameters. The shared epitope containing HLA-DRB1 alleles represent the most significant genetic risk for RA. Magnetic resonance and ultrasound imaging are very sensitive methods for erosion detection in early phase of the disease.
Ključne riječi
rheumatoid arthritis; early diagnosis; anti-CCP; HLA-DRB1
Hrčak ID:
129198
URI
Datum izdavanja:
28.7.2006.
Posjeta: 4.628 *