Izvorni znanstveni članak

https://doi.org/10.5599/admet.3.3.208

Specific frequency bands of amplitude low-frequency fluctuations in memory-related cognitive impairment: predicting Alzheimer’s disease

Yin Tian ; Bio - information College, ChongQing University of Posts and Telecommunications, ChongQing 400065, China
Zechao Ding ; Bio - information College, ChongQing University of Posts and Telecommunications, ChongQing 400065, China
Kin Yip Tam ; Faculty of Health Sciences, University of Macau, Macau, China
Zhongyan Wang ; Bio - information College, ChongQing University of Posts and Telecommunications, ChongQing 400065, China
Huiling Zhang ; Bio - information College, ChongQing University of Posts and Telecommunications, ChongQing 400065, China
Dechun Zhao ; Bio - information College, ChongQing University of Posts and Telecommunications, ChongQing 400065, China
Yi Zhao ; Bio - information College, ChongQing University of Posts and Telecommunications, ChongQing 400065, China
Wei Xu ; Bio - information College, ChongQing University of Posts and Telecommunications, ChongQing 400065, China
Shuxing Zheng ; Colleg of Computer Science and Technology, ChongQing University of Posts and Telecommunications, Ch ongQing 400065, China

Sažetak

Resting-state functional magnetic resonance imaging was utilized to measure the amplitude low frequency fluctuations (ALFF) in human subjects with Alzheimer’s disease (AD) and normal control (NC). Two specific frequency bands (Slow5: 0.01-0.027Hz and Slow4: 0.027-0.073Hz) were analysed in the main cognitive control related four subregions of the right ventral lateral prefrontal cortex (VLPFC), i.e. IFJ, posterior-VLPFC, mid-VLPFC, and anterior-VLPFC. Differences in ALFF values between the AD and the NC group were found throughout the subregions of the right VLPFC. Compared to normal control group, decreased ALFF values were observed in AD patients in the IFJ (in two given frequency bands), and the mid-VLPFC (in Slow5). In contrast, increased ALFF valued were observed in AD patients in the posterior- and anterior-VLPFC (in both Slow5 and Slow4), and also in the mid-VLPFC in Slow4. Moreover, significant ALFF differences between the IFJ and three other subregions of the right VLPFC were found. Furthermore, ALFF values in the right VLPFC showed significant correlations with the time course of disease. Taken together, our findings suggest that AD patients have largely abnormalities in intrinsic neural oscillations which are in line with the AD pathophysiology, and further reveal that the abnormalities are dependent on specific frequency bands. Thus, frequency-domain analyses of the ALFF may provide a useful tool to investigate the AD pathophysiology.

Ključne riječi

AD; ALFF; VLPFC; rs-fMRI; top-down modulation

Hrčak ID:

144319

URI

https://hrcak.srce.hr/144319

Datum izdavanja:

5.9.2015.

Posjeta: 1.501 *