Review article

SYSTEMIC PHARMACOLOGICAL TREATMENT OF PAIN IN RHEUMATIC DISEASE

Simeon Grazio
Ines Doko

Abstract

Pain is a cardinal symptom of rheumatic diseases and the most common reason for seeking medical
help. Pain relief has many benefi cial eff ects and is necessary for the functional recovery. A variety of drugs are used for
the treatment of pain in rheumatic diseases. Th ey usually include acetaminophen, nonsteroidal anti-rheumatic drugs,
and opioids (mostly weak opioids). Antidepressants and anticonvulsants can be used in cases with a predominant
neuropathic component. In this descriptive review we present up-to-date results of trials with systemic analgesic drugs
in rheumatic diseases, including nerve growth factor inhibitors and symptomatic slow-acting drugs for osteoarthritis.

Keywords

Rheumatic diseases – complications, drug therpapy; Chronic pain – drug therapy, etiology, physiopathology; Osteoarthritis – complications, drug therapy; Anti-infl ammatory agents, non-steroidal – adverse eff ects, pharmacology, therapeutic use; Acetaminophen – therapeutic use; Analgesics, opioid – adverse eff ects, pharmacology, therapeutic use; Receptor, nerve growth factor – antagonists and inhibitors; Antibodies, monoclonal, humanized – therapeutic use; Antidepressive agents, tricyclic – therapeutic use; Anticonvulsants – therapeutic use

Hrčak ID:

182836

URI

https://hrcak.srce.hr/182836

Publication date:

19.10.2016.

Article data in other languages: croatian

Visits: 2.512 *