Izvorni znanstveni članak

https://doi.org/10.5599/admet.626

Nicotinic acid in nanocontainers. Encapsulation and release from ion exchangers

Heinrich Altshuler ; Laboratory of Supramolecular Polymer Chemistry, Institute of Coal Chemistry and Material Science, Federal Research Center of Coal and Coal Chemistry, Siberian Branch of Russian Academy of Sciences, Kemerovo, 650000, Russian Federation
Elena Ostapova ; Laboratory of Supramolecular Polymer Chemistry, Institute of Coal Chemistry and Material Science, Federal Research Center of Coal and Coal Chemistry, Siberian Branch of Russian Academy of Sciences, Kemerovo, 650000, Russian Federation
Olga Altshuler ; Laboratory of Supramolecular Polymer Chemistry, Institute of Coal Chemistry and Material Science, Federal Research Center of Coal and Coal Chemistry, Siberian Branch of Russian Academy of Sciences, Kemerovo, 650000, Russian Federation
Galina Shkurenko ; Laboratory of Supramolecular Polymer Chemistry, Institute of Coal Chemistry and Material Science, Federal Research Center of Coal and Coal Chemistry, Siberian Branch of Russian Academy of Sciences, Kemerovo, 650000, Russian Federation
Natalya Malyshenko ; Laboratory of Supramolecular Polymer Chemistry, Institute of Coal Chemistry and Material Science, Federal Research Center of Coal and Coal Chemistry, Siberian Branch of Russian Academy of Sciences, Kemerovo, 650000, Russian Federation
Sergey Lyrschikov ; Laboratory of Supramolecular Polymer Chemistry, Institute of Coal Chemistry and Material Science, Federal Research Center of Coal and Coal Chemistry, Siberian Branch of Russian Academy of Sciences, Kemerovo, 650000, Russian Federation
Roman Parshkov ; Laboratory of Supramolecular Polymer Chemistry, Institute of Coal Chemistry and Material Science, Federal Research Center of Coal and Coal Chemistry, Siberian Branch of Russian Academy of Sciences, Kemerovo, 650000, Russian Federation

Sažetak

The paper is devoted to the study of the ion exchange encapsulation of nicotinic acid in nanocontainers on polymer matrices. Dowex-50 cation exchanger, sulphonated polymer based on metacyclophanoctol, polymer zirconium phosphate, and strongly basic Dowex-1 anion exchanger are used as polymer matrices. It was confirmed that commercial ion exchangers can encapsulate up to 0.64 g of nicotinic acid per gram of polymer. The high elution rate of nicotinic acid from nanocontainers via the ion exchange mechanism makes it possible to achieve the desired pharmacokinetics of drug release in vivo.

Ključne riječi

nicotinic acid; encapsulation; ion exchange polymers; pharmacokinetics

Hrčak ID:

217380

URI

https://hrcak.srce.hr/217380

Datum izdavanja:

23.2.2019.

Posjeta: 1.228 *