Izvorni znanstveni članak

https://doi.org/10.5599/admet.668

Prediction of ADME-Tox properties and toxicological endpoints of triazole fungicides used for cereals protection

Ionuț Mădălin Gridan ; Department of Biology-Chemistry and Advanced Environmental Research Laboratories, West University of Timișoara, Timișoara, Romania
Alecu Aurel Ciorsac ; Department of Physical Education and Sport, University Politehnica Timișoara, Timișoara, Romania
Adriana Isvoran orcid.org/0000-0002-3068-2642 ; Department of Biology-Chemistry and Advanced Environmental Research Laboratories, West University of Timișoara, Timișoara, Romania

Sažetak

Within this study we have considered 9 triazole fungicides that are approved to be used in European Union for protecting cereals: cyproconazole, epoxiconazole, flutriafol, metconazole, paclobutrazole, tebuconazole, tetraconazole, triadimenol and triticonazole. We have summarized the few available data that support their effects on humans and used various computational tools to obtain a widely view concerning their possible harmful effects on humans. The results of our predictive study reflect that all triazole fungicides considered in this study reveal good oral bioavailability, are envisaged as being able to penetrate the blood brain barrier and to interact with P-glycoprotein and with hepatic cytochromes. The predictions concerning the toxicological endpoints for the investigated triazole fungicides reveal that they. reflect potential of skin sensitization, of blockage of the hERG K+ channels and of endocrine disruption, that they have not mutagenic potential and their carcinogenic potential is not clear. Epoxiconazole and triadimenol are predicted to have the highest potentials of producing numerous harmful effects on humans and their use should be avoided or limited.

Ključne riječi

oral bioavailability; endocrine disruption; carcinogenicity; mutagenicity; cardiotoxicity

Hrčak ID:

224000

URI

https://hrcak.srce.hr/224000

Datum izdavanja:

5.8.2019.

Posjeta: 1.722 *