Socijalna psihijatrija, Vol. 54 No. 2, 2026.
Sažetak sa skupa
https://doi.org/10.24869/spsih.2026.334
When Psychotropic Medications Become the Prime Suspect: The Diagnostic Dilemma of Acute Liver Injury
Valentin Kordić
; Klinički bolnički centar Osijek, Josipa Huttlera 4, 31000 Osijek, Hrvatska; Medicinski fakultet Osijek, Sveučilište Josipa Jurja Strossmayera u Osijeku, Josipa Huttlera 4, 31000 Osijek, Hrvatska
*
Ena Bandov
; Klinički bolnički centar Osijek, Josipa Huttlera 4, 31000 Osijek, Hrvatska
Anamarija Petek Erić
; Klinički bolnički centar Osijek, Josipa Huttlera 4, 31000 Osijek, Hrvatska; Medicinski fakultet Osijek, Sveučilište Josipa Jurja Strossmayera u Osijeku, Josipa Huttlera 4, 31000 Osijek, Hrvatska
Lucija Kljaić
; Nacionalna memorijalna bolnica „Dr. Juraj Njavro“, Županijska ulica 35, 32000 Vukovar, Hrvatska
Filip Kralik
; Klinički bolnički centar Osijek, Josipa Huttlera 4, 31000 Osijek, Hrvatska
Dunja Degmečić
; Klinički bolnički centar Osijek, Josipa Huttlera 4, 31000 Osijek, Hrvatska; Medicinski fakultet Osijek, Sveučilište Josipa Jurja Strossmayera u Osijeku, Josipa Huttlera 4, 31000 Osijek, Hrvatska
* Dopisni autor.
Sažetak
Hepatotoxicity associated with the use of psychotropic
medications is a rare but clinically important
adverse effect that poses a diagnostic challenge
and requires systematic differential diagnosis
and a multidisciplinary approach. This paper
presents the case of a 41-year-old female patient
treated for anxiety-depressive symptomatology
who developed acute liver injury during psychopharmacological
treatment. To clarify the etiology,
the diagnostic workup included laboratory testing,
serological testing for viral hepatitis, immunological
and radiological assessment, and pathohistological
analysis, along with a psychiatric consultative
evaluation of possible psychopharmacotherapy-
induced hepatotoxicity. The investigations and
histopathological analysis indicated acute liver injury but did not clarify the etiology of the liver
damage or confirm a possible drug-induced cause.
Despite the unresolved drug-related etiology,
gradual recovery with improvement of laboratory
parameters occurred following reduction of psychopharmacotherapy
and supportive treatment.
By presenting this case, we aim to highlight the
importance of a multidisciplinary approach and
comprehensive diagnostic workup in determining
the etiology of acute liver injury and in making
diagnostic and therapeutic decisions. Although
psychotropic medications are often implicated in
acute liver injury, their causal role cannot always
be reliably confirmed or excluded.
Ključne riječi
psychotropic medications; hepatotoxicity; multidisciplinarity
Hrčak ID:
353021
URI
Datum izdavanja:
15.6.2026.
Posjeta: 0 *