Pregledni rad
Biocatalytic Synthesis of Chiral Pharmaceutical Intermediates
Ramesh N. Patel
; Process R & D, Bristol-Myers Squibb, New Brunswick, NJ 08903, USA
Sažetak
The production of single enantiomers of drug intermediates has become increasingly important in the pharmaceutical industry. Chiral intermediates and fine chemicals are in high demand from both the pharmaceutical and agrochemical industries for the preparation of bulk drug substances and agricultural products. The enormous potential of microorganisms and enzymes for the transformation of synthetic chemicals with high chemo-, regio- and enantioselectivities has been demonstrated. In this article, biocatalytic processes are described for the synthesis of chiral pharmaceutical intermediates.
Ključne riječi
biocatalysis; chiral intermediates; anticancer; antihypertensive; anti-infective; enantioselective enzymatic de-protection
Hrčak ID:
110885
URI
Datum izdavanja:
15.12.2004.
Posjeta: 4.797 *