Review article

Biocatalytic Synthesis of Chiral Pharmaceutical Intermediates

Ramesh N. Patel ; Process R & D, Bristol-Myers Squibb, New Brunswick, NJ 08903, USA

Abstract

The production of single enantiomers of drug intermediates has become increasingly important in the pharmaceutical industry. Chiral intermediates and fine chemicals are in high demand from both the pharmaceutical and agrochemical industries for the preparation of bulk drug substances and agricultural products. The enormous potential of microorganisms and enzymes for the transformation of synthetic chemicals with high chemo-, regio- and enantioselectivities has been demonstrated. In this article, biocatalytic processes are described for the synthesis of chiral pharmaceutical intermediates.

Keywords

biocatalysis; chiral intermediates; anticancer; antihypertensive; anti-infective; enantioselective enzymatic de-protection

Hrčak ID:

110885

URI

https://hrcak.srce.hr/110885

Publication date:

15.12.2004.

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