Medicina Fluminensis, Vol. 55 No. 4, 2019.
Other
https://doi.org/10.21860/medflum2019_227130
Raynaud’s phenomenom as a first manifestation of high grade serosus carcinoma – case report
Sara Turina
; Sveučilište u Rijeci, Medicinski fakultet, Rijeka, Hrvatska
Senija Eminović
; Zavod za patologiju i patološku anatomiju, Sveučilište u Rijeci, Medicinski fakultet, Rijeka, Hrvatska
Ani Mihaljević Ferari
; Zavod za onkologiju, KBC Rijeka, Rijeka, Hrvatska
Emina Babarović
; Zavod za patologiju i patološku anatomiju, Sveučilište u Rijeci, Medicinski fakultet, Rijeka, Hrvatska
Tatjana Zekić
; Zavod za Reumatologiju i kliničku imunologiju, KBC Rijeka, Rijeka, Hrvatska
Srđan Novak
orcid.org/0000-0001-8870-4704
; Zavod za Reumatologiju i kliničku imunologiju, KBC Rijeka, Rijeka, Hrvatska
Abstract
Aim: To present a case of a patient with Raynaud’s phenomenom as the first manifestation of a high grade serosus carcinoma. Case report: A 47-year-old female has been referred to the Department of Rheumatology and Clinical Immunology due to the positive antinuclear antibodies and Raynaud’s phenomena. Both clinical examination and laboratory treatment excluded systemic connective tissue disease. Abdominal ultrasound revealed cystic formation in the pelvis area. Tumor markers CA-125, HE-4 were elevated. PET / CT analysis (positron emission tomography/computed tomography) observed increased radiotracer uptake involving supra/retroclavicular lymph nodes, pelvic and paraortal. The cytology of the lymph node at the neck indicated a metastatic weak-bound adenocarcinoma. Left and right ovarian laparoscopy, double salpingectomy and pelvic lymphadenectomy were performed. The pathological analysis confirmed that it was intraepithelial serous high grade fallopian tube cancer. The patient went to 6 cycles of chemotherapy (Paclitaxel and Carboplatin). Follow up CT didn’t show any signs of dissemination of the underlying disease. The patient is currently in a good general condition and treated with Olaparib. Raynaud’s phenomenon is significantly improved. Conclusion: Serous high-grade cancer can be presented in an atipic manner. The sudden occurrence of Raynaud’s phenomena in younger people should raise doubts about possible malignancy.
Keywords
fallopian tube cancer; high grade serosus carcinoma; ovarian cancer; Raynaud’s phenomenom
Hrčak ID:
227130
URI
Publication date:
1.12.2019.
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