Izvorni znanstveni članak
https://doi.org/10.15644/asc56/3/1
Clinical Prospective Assessment of Genotoxic Effects of Dental Implants in Gingival Epithelial Cells
Mirna Radović
; Privatna dentalna ordinacija, Solin, Hrvatska
Lidia Gavić
; Katedra za restaurativnu dentalne medicinu i endodonciju Studija dentalne medicine Medicinskog fakulteta Sveučilišta u Splitu, Hrvatska
Daniel Jerković
; Odjel za makislofacijalnu kirurgiju Kliničkoga bolničkoga centra Split, Hrvatska
Davor Željezić
; Jedinica za mutagenezu Instituta za medicinska istraživanja i medicinu rada, Zagreb, Hrvatska
Jasna Puizina
; Odjel za biologiju Prirodoslovno-matematičkoga fakulteta Sveučilišta u Splitu, Hrvatska
Ivan Srzentić
; Privatna dentalna ordinacija, Zadar, Hrvatska
Ema Puizina Mladinić
; Odjel za makislofacijalnu kirurgiju Kliničkoga bolničkoga centra Split, Hrvatska
Antonija Tadin
; Katedra za restaurativnu dentalne medicinu i endodonciju Studija dentalne medicine Medicinskog fakulteta Sveučilišta u Splitu, Hrvatska
Sažetak
Objectives: Although titanium-based implants are considered bioinert, it has been found that they
are subject to corrosion and wear. This study aimed to evaluate the cytotoxic and genotoxic potential
of two implant systems in gingival epithelial cells. Material and methods: Gingival swabs were taken three times from 91 subjects. The first swab was taken before dental implant placement, the second swab 90 days after dental implant placement and the third swab 21 days following the healing
abutment placement. DNA damage was analyzed using the micronucleus test. Tested dental implants
with corresponding healing abutments were Ankylos and Dentium SuperLine. Results: Of all scored
forms of cytogenetic damage in gingival cells of individuals after implementation of tested dental implant systems, only an increase in the number of binucleated cells (P ≤ 0.001) was significant in contrast to control values for both tested implant systems, 90 days after dental implant placement and
21 days following the healing abutment placement. Conclusion: It may be concluded that there are
no titanium-based implant dependent cytogenetic damage in gingival epithelial cells. A slight increase in cytogenetic damage has been observed but it is of no biological relevance and might be associated with healing abutment induced effect.
Ključne riječi
Dental Implants; Titanium; Corrosion; Micronucleus Tests; Gingiva; Epithelial Cells; Biocompatibility; Micronucleus Assay
Hrčak ID:
283921
URI
Datum izdavanja:
29.9.2022.
Posjeta: 1.599 *