Pregledni rad

PRIMARY VITREORETINAL LYMPHOMA: AN OPHTHALMOLOGIST PERSPECTIVE ON DIAGNOSIS AND TREATMENT

NATASA VIDOVIC VALENTINCIC ; Očna bolnica, Univerzitetski klinički centar, Ljubljana, Slovenija; Medicinski fakultet, Sveučilište Ljubljana, Ljubljana, Slovenija
ANA GORNIK ; Očna bolnica, Univerzitetski klinički centar, Ljubljana, Slovenija
SASA POCKAR ; Central Manchester University Hospitals NHS Foundation Trust – Manchester Royal Eye Hospital (MREH), Manchester, Velika Britanija
MOJCA GLOBOCNIK PETROVIC ; Očna bolnica, Univerzitetski klinički centar, Ljubljana, Slovenija; Medicinski fakultet, Sveučilište Ljubljana, Ljubljana, Slovenija

Sažetak

Primary vitreoretinal lymphoma (PVRL) is a rare subset of central nervous system lymphoma occurring primarily in the vitreous and retina. Often presenting as a masquerade syndrome mimicking infectious or non-infectious uveitis, PVRL presents a diagnostic and therapeutic challenge. A vitreal or retinal biopsy is essential for diagnosis. This paper reviews recent advances and updates in the diagnosis and treatment of PVRL with a focus on intravitreal chemotherapy. Current diagnostic techniques for PVRL are demanding and detailed clinical history, examination, ocular and central nervous system imaging with immunohistochemistry, fl ow cytometry, molecular and genetic analysis are needed. In the last few years, local intravitreal treatment in cases with isolated PVRL is the topic of many published papers, however, the number of patients involved is small and treatment recommendations are not standardized and unique.

Ključne riječi

lymphoma; masquerade; intraocular; extranodal; intravitreal treatment; local chemotherapy

Hrčak ID:

294448

URI

https://hrcak.srce.hr/294448

Datum izdavanja:

27.2.2023.

Podaci na drugim jezicima: hrvatski

Posjeta: 384 *