Review article

PRIMARY VITREORETINAL LYMPHOMA: AN OPHTHALMOLOGIST PERSPECTIVE ON DIAGNOSIS AND TREATMENT

NATASA VIDOVIC VALENTINCIC ; Eye Hospital, University Medical Centre, Ljubljana, Slovenia; Faculty of Medicine, University of Ljubljana, Slovenia
ANA GORNIK ; Eye Hospital, University Medical Centre, Ljubljana, Slovenia
SASA POCKAR ; Central Manchester University Hospitals NHS Foundation Trust – Manchester Royal Eye Hospital (MREH), Manchester, Great Britain
MOJCA GLOBOCNIK PETROVIC ; Eye Hospital, University Medical Centre, Ljubljana, Slovenia; Faculty of Medicine, University of Ljubljana, Slovenia

Abstract

Primary vitreoretinal lymphoma (PVRL) is a rare subset of central nervous system lymphoma occurring primarily in the vitreous and retina. Often presenting as a masquerade syndrome mimicking infectious or non-infectious uveitis, PVRL presents a diagnostic and therapeutic challenge. A vitreal or retinal biopsy is essential for diagnosis. This paper reviews recent advances and updates in the diagnosis and treatment of PVRL with a focus on intravitreal chemotherapy. Current diagnostic techniques for PVRL are demanding and detailed clinical history, examination, ocular and central nervous system imaging with immunohistochemistry, fl ow cytometry, molecular and genetic analysis are needed. In the last few years, local intravitreal treatment in cases with isolated PVRL is the topic of many published papers, however, the number of patients involved is small and treatment recommendations are not standardized and unique.

Keywords

lymphoma; masquerade; intraocular; extranodal; intravitreal treatment; local chemotherapy

Hrčak ID:

294448

URI

https://hrcak.srce.hr/294448

Publication date:

27.2.2023.

Article data in other languages: croatian

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