ADMET and DMPK, Vol. 13 No. 6, 2025.
Original scientific paper
https://doi.org/10.5599/admet.2968
Efficient electrochemical determination of dopamine in the presence of uric acid in real samples using tungsten disulfide nanostructure modified electrode
Ibrahim Ayad Jihad
; 1Department of chemistry and biochemistry, Al-Zahraa College of medicine, University of Basrah, Iraq
*
Thekrayat Joodi Jassim
; College of Education/Department of Chemistry/University of Sumer, Thi_Qar,Iraq
Zainab Naeif Mageed
; Department of Chemistry, College of Science, Mustansiriah University, Baghdad, Iraq
* Corresponding author.
Abstract
Background and purpose: Research on the detection of uric acid (URA) and dopamine (DPA) is ongoing because of the difficulties posed by their closely overlapping oxidation potentials. Tungsten disulfide nanostructures have become attractive electrode materials to address this problem due to their low toxicity, low cost, easy production, and strong catalytic activity. Experimental approach: For voltammetric detection of compounds, we present the creation of an electrochemical sensor based on a glassy carbon electrode modified with tungsten disulfide nanostructures. Key results: According to electrochemical analyses, the manufactured sensor performed exceptionally well, having a broad LDR of 0.03 to 600.0 μM and a low LOD of 10 nM for DPA. Conclusion: The effective detection of compounds in real samples, such as injections and urine, with acceptable recovery rates further confirmed the suggested sensor's practical usefulness. In addition to offering a viable method for creating tungsten disulfide-based modified electrodes, this study holds promise for future applications in bioanalytical sensing and clinical diagnostics.
Keywords
Central nervous system; cardiovascular system; nanostructured materials; chemically modified electrode
Hrčak ID:
342109
URI
Publication date:
9.10.2025.
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