Ostalo

https://doi.org/10.20471/acc.2026.65.02.20

Konsenzusne preporuke Hrvatskoga endokrinog društva za dijagnostiku i liječenje akromegalije

Silvija Canecki-Varžić ; Department of Endocrinology, Osijek University Hospital Center, Osijek, Croatia; Department of Pathophysiology, Faculty of Medicine, Josip Juraj Strossmayer University of Osijek, Osijek, Croatia; Department of Clinical Medicine, Faculty of Dental Medicine and Health, Josip Juraj Strossmayer University of Osijek, Osijek, Croatia
Ines Bilić-Ćurčić orcid.org/0000-0002-8861-5987 ; Department of Endocrinology, Osijek University Hospital Center, Osijek, Croatia; Department of Pharmacology, Faculty of Medicine, Josip Juraj Strossmayer University of Osijek, Osijek, Croatia *
Ivana Prpić-Križevac ; Department of Endocrinology, Osijek University Hospital Center, Osijek, Croatia; Department of Pathophysiology, Faculty of Medicine, Josip Juraj Strossmayer University of Osijek, Osijek, Croatia
Gorana Mirošević ; Mladen Sekso Department of Endocrinology, Diabetes and Metabolic Diseases, Sestre milosrdnice University Hospital Center, Zagreb, Croatia; University of Zagreb, School of Medicine, Zagreb, Croatia; University of Zagreb, School of Dental Medicine, Zagreb, Croatia
Dubravka Jurišić-Eržen ; Department of Endocrinology and Diabetology, Rijeka University Hospital Center, Rijeka, Croatia; Department of Internal Medicine, School of Medicine, University of Rijeka, Rijeka, Croatia
Tina Tićinović-Kurir ; Department of Endocrinology, Diabetes and Metabolic Diseases, Split University Hospital Center, Split, Croatia; Department of Pathophysiology, School of Medicine, University of Split, Split, Croatia
Mladen Krnić ; Department of Endocrinology, Diabetes and Metabolic Diseases, Split University Hospital Center, Split, Croatia; Department of Pathophysiology, School of Medicine, University of Split, Split, Croatia
Tamara Turk Wensween ; Department of Internal Medicine, School of Medicine, University of Rijeka, Rijeka, Croatia; Center for Diabetes, Endocrinology and Cardiometabolism, Opatija Thalassotherapia, Opatija, Croatia
Mateja Strinović Morić ; Mladen Sekso Department of Endocrinology, Diabetes and Metabolic Diseases, Sestre milosrdnice University Hospital Center, Zagreb, Croatia
Domagoj Gajski ; Department of Neurosurgery, Sestre milosrdnice University Hospital Center, Zagreb, Croatia; Department of Anatomy, University of Applied Health Sciences, Zagreb, Croatia
Danijela Fabris Vitković orcid.org/0000-0002-2976-398X ; Department of Endocrinology and Diabetology, Pula General Hospital, Pula, Croatia; Nursing Studies at the Faculty of Medicine, Juraj Dobrila University, Pula, Croatia
Marina Gradišer orcid.org/0000-0002-6308-1384 ; Department of Internal Medicine, Čakovec County Hospital, Čakovec, Croatia; School of Medicine, University of Split, Split, Croatia
Miro Bakula ; Division of Endocrinology, Diabetes and Metabolic Diseases, Department of Internal Medicine, Sveti Duh University Hospital, Zagreb, Croatia; School of Medicine, University of Zagreb, Zagreb, Croatia

* Dopisni autor.

Sažetak

Akromegalija je rijedak poremećaj hipofize koji je povezan sa značajnom smrtnošću. Cilj ove konsenzusne izjave
jest pružiti preporuke za dijagnostiku i liječenje temeljene na dokazima, prilagođene hrvatskom zdravstvenom
sustavu. Multidisciplinarni panel stručnjaka sustavno je pregledao međunarodne smjernice i dostupne dokaze
primjenjujući pristup za procjenu razine sigurnosti dokaza i snage preporuka GRADE. Preporuke obuhvaćaju dijagnostiku,
slikovne metode, kirurško liječenje, farmakoterapiju (somatostatinske analoge prve i druge generacije,
pegvisomant, dopaminske agoniste te kombiniranu terapiju), radioterapiju, praćenje bolesnika te upravljanje
supostojećim bolestima. Tablica sa sažetim i rangiranim preporukama pruža praktične smjernice za kliničku primjenu.
Ove konsenzusne preporuke nude standardizirane, na dokazima utemeljene smjernice za dijagnostiku
i liječenje akromegalije s ciljem poboljšanja ishoda liječenja bolesnika i unaprjeđenja te usklađivanja skrbi na
nacionalnoj razini.

Ključne riječi

Akromegalija; Inzulinu sličan čimbenik rasta 1 (IGF-1); Hormon rasta; Neoplazme hipofize; Liječenje; Hrvatska

Hrčak ID:

347739

URI

https://hrcak.srce.hr/347739

Datum izdavanja:

11.6.2026.

Podaci na drugim jezicima: engleski

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