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https://doi.org/10.20471/acc.2026.65.02.20

Croatian Endocrine Society Consensus Statement on Diagnosis and Management of Acromegaly

Silvija Canecki-Varžić ; Department of Endocrinology, Osijek University Hospital Center, Osijek, Croatia; Department of Pathophysiology, Faculty of Medicine, Josip Juraj Strossmayer University of Osijek, Osijek, Croatia; Department of Clinical Medicine, Faculty of Dental Medicine and Health, Josip Juraj Strossmayer University of Osijek, Osijek, Croatia
Ines Bilić-Ćurčić orcid.org/0000-0002-8861-5987 ; Department of Endocrinology, Osijek University Hospital Center, Osijek, Croatia; Department of Pharmacology, Faculty of Medicine, Josip Juraj Strossmayer University of Osijek, Osijek, Croatia *
Ivana Prpić-Križevac ; Department of Endocrinology, Osijek University Hospital Center, Osijek, Croatia; Department of Pathophysiology, Faculty of Medicine, Josip Juraj Strossmayer University of Osijek, Osijek, Croatia
Gorana Mirošević ; Mladen Sekso Department of Endocrinology, Diabetes and Metabolic Diseases, Sestre milosrdnice University Hospital Center, Zagreb, Croatia; University of Zagreb, School of Medicine, Zagreb, Croatia; University of Zagreb, School of Dental Medicine, Zagreb, Croatia
Dubravka Jurišić-Eržen ; Department of Endocrinology and Diabetology, Rijeka University Hospital Center, Rijeka, Croatia; Department of Internal Medicine, School of Medicine, University of Rijeka, Rijeka, Croatia
Tina Tićinović-Kurir ; Department of Endocrinology, Diabetes and Metabolic Diseases, Split University Hospital Center, Split, Croatia; Department of Pathophysiology, School of Medicine, University of Split, Split, Croatia
Mladen Krnić ; Department of Endocrinology, Diabetes and Metabolic Diseases, Split University Hospital Center, Split, Croatia; Department of Pathophysiology, School of Medicine, University of Split, Split, Croatia
Tamara Turk Wensween ; Department of Internal Medicine, School of Medicine, University of Rijeka, Rijeka, Croatia; Center for Diabetes, Endocrinology and Cardiometabolism, Opatija Thalassotherapia, Opatija, Croatia
Mateja Strinović Morić ; Mladen Sekso Department of Endocrinology, Diabetes and Metabolic Diseases, Sestre milosrdnice University Hospital Center, Zagreb, Croatia
Domagoj Gajski ; Department of Neurosurgery, Sestre milosrdnice University Hospital Center, Zagreb, Croatia; Department of Anatomy, University of Applied Health Sciences, Zagreb, Croatia
Danijela Fabris Vitković orcid.org/0000-0002-2976-398X ; Department of Endocrinology and Diabetology, Pula General Hospital, Pula, Croatia; Nursing Studies at the Faculty of Medicine, Juraj Dobrila University, Pula, Croatia
Marina Gradišer orcid.org/0000-0002-6308-1384 ; Department of Internal Medicine, Čakovec County Hospital, Čakovec, Croatia; School of Medicine, University of Split, Split, Croatia
Miro Bakula ; Division of Endocrinology, Diabetes and Metabolic Diseases, Department of Internal Medicine, Sveti Duh University Hospital, Zagreb, Croatia; School of Medicine, University of Zagreb, Zagreb, Croatia

* Corresponding author.

Abstract

Acromegaly is a rare pituitary disorder with significant morbidity. This consensus
statement aims to provide evidence-based diagnostic and management
recommendations adapted to the Croatian setting. A multidisciplinary panel
systematically reviewed international guidelines and evidence, applying the
GRADE approach to assess certainty and strength of recommendations. Recommendations
cover diagnosis, imaging, surgery, pharmacotherapy (first- and
second-generation somatostatin receptor ligands, pegvisomant, dopamine
agonists, combination therapy), radiotherapy, follow-up, and comorbidity management.
A graded summary table provides practical guidance. These consensus
recommendations offer standardized, evidence-based guidance for the diagnosis
and management of acromegaly, aiming to improve patient outcomes
and harmonize care across Croatia.

Keywords

Acromegaly; Insulin-like growth factor 1 (IGF-1); Growth hormone; Pituitary neoplasms; Therapy; Croatia

Hrčak ID:

347739

URI

https://hrcak.srce.hr/347739

Publication date:

11.6.2026.

Article data in other languages: croatian

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