Izvorni znanstveni članak

https://doi.org/https://doi.org/10.5599/admet.3246

A high-performance voltammetric sensor based on Co/Ni-metal-organic framework modified electrode for the determination of dopamine in the presence of tyrosine

Dhurgham Hani Kadhim Alalwan ; Department of Pharmaceutical Chemistry, College of Pharmacy, University of Kerbala, Karbala, Iraq
Saja Haider Fadhil ; Department of Pharmaceutical Chemistry, College of Pharmacy, University of Kerbala, Karbala, Iraq
Muntaha Mahmood Abed ; Department of Pharmaceutical Chemistry, College of Pharmacy, University of Kerbala, Karbala, Iraq
Noor Kareem Aead ; Department of Pharmaceutical Chemistry, College of Pharmacy, University of Kerbala, Karbala, Iraq
Hussein Ali Qabel ; Department of Pharmaceutical Chemistry, College of Pharmacy, University of Kerbala, Karbala, Iraq *

* Dopisni autor.

Sažetak

Background and purpose: The central nervous, renal, hormonal, and cardiovascular systems depend on dopamine. Therefore, a straightforward, sensitive, and selective method for detecting DA is needed to track DA levels in the human body. Experimental approach: Co/Ni-metal-organic framework was developed via a one-pot hydrothermal synthesis. The electrochemical sensor developed for dopamine measurement used Co/Ni-metal-organic framework materials on screen-printed carbon electrodes. The Co/Ni-metal-organic framework on a screen-printed carbon electrode exhibits excellent electrocatalytic activity for dopamine oxidation, owing to its high electron-transfer rate. Key results: The electrocatalytic activity of Co/Ni-metal-organic framework on a screen-printed carbon electrode significantly improves dopamine oxidation, yielding higher peak currents and lower oxidation potentials than the bare screen-printed carbon electrode. The sensor detected dopamine with a linear response, ranging from 0.01 to 660.0 µmol L-1, with a limit of detection of 0.007 µmol L-1. To measure tyrosine and dopamine simultaneously, differential pulse voltammetry was used. The separation between tyrosine and dopamine reached 150 mV. Conclusion: Successful target-analyte identification using the proposed voltammetric sensor was achieved, detecting both dopamine and tyrosine in actual sample tests.

Ključne riječi

Disposable sensor; differential pulse voltammetry; screen printed electrode; chronoamperometry; cyclic voltammetry; real sample analysis

Hrčak ID:

350223

URI

https://hrcak.srce.hr/350223

Datum izdavanja:

7.5.2026.

Posjeta: 0 *