Skoči na glavni sadržaj

Biochemia Medica, Vol. 19 No. 1, 2009.

Ostalo

Bisalbuminemia in a male Croatian patient with sarcoidosis

Ana-Maria Šimundić orcid id orcid.org/0000-0002-2391-5241 ; Klinički zavod za kemiju, KB „Sestre milosrdnice", Zagreb, Hrvatska
Marijana Miler ; Klinički zavod za kemiju, KB „Sestre milosrdnice", Zagreb, Hrvatska
Nora Nikolac ; Klinički zavod za kemiju, KB „Sestre milosrdnice", Zagreb, Hrvatska
Elizabeta Topić ; Klinički zavod za kemiju, KB „Sestre milosrdnice", Zagreb, Hrvatska
Dubravka Čaržavec ; Klinika za unutarnje bolesti, KB „Sestre milosrdnice", Zagreb, Hrvatska
Branka Milanović ; Klinički zavod za kemiju, KB „Sestre milosrdnice", Zagreb, Hrvatska
Vladimir Stančić ; Klinika za unutarnje bolesti, KB „Sestre milosrdnice", Zagreb, Hrvatska

Puni tekst: hrvatski pdf 174 Kb

str. 95-100

preuzimanja: 444

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Puni tekst: engleski pdf 174 Kb

str. 95-100

preuzimanja: 590

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Sažetak

Background: Inherited bisalbuminemia is rare, mostly benign state, which has so far been described in several pathological conditions. Two genetic variants have already been described in two Croatian families. Herein we report a new case of bisalbuminemia in a Croatian male patient with sarcoidosis.
Methods: The patient was referred by a general practitioner to our hospital for a diagnostic work up for suspected sarcoidosis. Serum capillary protein electrophoresis was performed with automated capillary electrophoresis system.
Results: Based on laboratory and pathologic findings, diagnosis of sarcoidosis was confirmed. Serum electrophoresis revealed two distinct albumin bands. Additional albumin variant was slow-migrating. The slow and a normal band made up for 0.48 and 0.51 of the total albumin, respectively. The patient's sister was also bisalbuminemic.
Conclusions: This is a new case of inherited bisalbuminemia in a patient with sarcoidosis. Whether bisalbuminemia has any relevance to sarcoidosis, remains to be elucidated. Clinical chemists and clinicians should be alerted by every case of either inherited or acquired albumin variant, because it could provide insight into the protein evolution as well as the physical, chemical and molecular characteristics of albumin.

Ključne riječi

bisalbuminemia; capillary zone electrophoresis; genetic heterogeneity; sarcoidosis; serum albumin

Hrčak ID:

32271

URI

https://hrcak.srce.hr/32271

Datum izdavanja:

5.2.2009.

Podaci na drugim jezicima: hrvatski

Posjeta: 2.837 *