Infektološki glasnik, Vol. 42 No. 4, 2022.
Pregledni rad
https://doi.org/10.37797/ig.42.4.3
The role of serology in diagnostics of urogenital Chlamydia trachomatis infections
Ivana Puškarić
; Klinika za infektivne bolesti „Dr. Fran Mihaljević“, Zagreb, Hrvatska
*
Oktavija Đaković Rode
orcid.org/0000-0001-8023-4314
; Klinika za infektivne bolesti „Dr. Fran Mihaljević“, Zagreb, Hrvatska
*
Snježana Židovec Lepej
; Klinika za infektivne bolesti „Dr. Fran Mihaljević“, Zagreb, Hrvatska
Tomislava Skuhala
; Klinika za infektivne bolesti „Dr. Fran Mihaljević“, Zagreb, Hrvatska
Alemka Markotić
; Klinika za infektivne bolesti „Dr. Fran Mihaljević“, Zagreb, Hrvatska
Višnja Škerk
; Klinika za infektivne bolesti „Dr. Fran Mihaljević“, Zagreb
* Dopisni autor.
Sažetak
Chlamydia trachomatis is the most common cause of bacterial sexually transmitted infections. Chlamydial sexually transmitted infections include lymphogranuloma venereum caused by serovars L1-L3 and other urogenital infections caused by serovars D-K. C. trachomatis can infect newborns through perinatal transmission.
The biggest challenge in prevention of Chlamydial infections is a significant proportion of asympthomatic infections, about 70% in women, and 50% in men, resulting in great potential for further infection spread. Although C. trachomatis infection is usually asympthomatic, in women can cause urethritis, cervicitis, endometritis, pelvic inflammatory disease, chronic pelvic pain, tubal factor infertility, ectopic pregnancy, proctitis, conjunctivitis, reactive arthritis, Reiter's syndrome, and in pregnant women also preterm labor and postpartal endometritis. In men, infection can cause urethritis, prostatitis, epididymitis, proctitis in homosexual men, conjunctivitis, reactive arthritis, Reiter's syndrome. C. trachomatis can be transmitted to newborns during delivery and cause health complications such as conjunctivitis and pneumonia.
Laboratory diagnosis of C. trachomatis infection can be divided into direct and indirect diagnostic tests. Direct tests include isolation in cell culture, antigen detection, nucleic acid hybridization (NAH) and nucleic acid amplification test (NAAT) which consists of polymerase chain reaction (PCR), ligase chain reaction (LCR), strand displacement amplification (SDA) and transcription mediated amplification (TMA). Indirect method is based on detection of IgM, IgG and IgA antibodies.
Clinical specimens for direct diagnostic test include endocervical swab, endourethral swab, rectal swab, conjunctival swab and for NAAT also first-void urine and vaginal swab.
Ključne riječi
Chlamydia trachomatis; genital infections; diagnostics; serology
Hrčak ID:
338852
URI
Datum izdavanja:
19.11.2025.
Posjeta: 602 *