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Filaggrin Single Nucleotide Polymorphisms in Atopic Dermatitis

Mojdeh Khaledi
Akbar Fotouhi
Elham Farhadi
Behnaz Mahdaviani
Soheila Sotoudeh
Mehdi Tavakoli
Nasrin Behniafard
Mohammad Gharagozlou
Nima Rezaei

Sažetak

Atopic Dermatitis (AD) is a relapsing chronic pruritic inflammatory disease of skin in which no monogenic cause has been identified so far. Meanwhile Filaggrin (FLG) gene is considered as the most important gene associated with predisposition to the disease.

One hundred and six patients with AD and 105 healthy individuals were enrolled in this study. Real time polymerase chain reaction was performed to determine frequencies of alleles and genotype in six variants of FLG gene.

Atopic dermatitis (AD) is a relapsing chronic pruritic inflammatory disease of skin for which no monogenic cause has been identified so far. Meanwhile, the filaggrin (FLG) gene is considered as the most important gene associated with predisposition to the disease.

One hundred and six patients with AD and 105 healthy individuals were enrolled in this study. Real time polymerase chain reaction was performed to determine frequencies of alleles and genotype in six variants of the FLG gene. The frequencies of allele A in variants of rs3126065, rs2786680, and rs1933063 as well as allele C in variant rs3814300 were 100%. There was no significant difference between allele frequencies in variants rs2485518 and rs3814299. The only genotypes in variants of rs3814299 and rs2485518 were GG and CC, respectively, with no significant difference between the patients and controls. This study demonstrated that there was no significant association between polymorphisms of FLG gene variants and AD.

Ključne riječi

Hrčak ID:

126594

URI

https://hrcak.srce.hr/126594

Datum izdavanja:

10.9.2014.

Posjeta: 2.245 *