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Veterinarski arhiv, Vol. 85 No. 2, 2015.

Izvorni znanstveni članak

Evaluation of the healing potential of earthworm coelomic fluid in full thickness skin wounds in rabbits.

Ran V. Singh ; Division of Animal Genetics, Indian Veterinary Research Institute-Izatnagar, Bareilly, India
Hari P. Aithal ; Division of Surgery, Indian Veterinary Research Institute-Izatnagar, Bareilly, India
Prakash Kinjavdekar ; Division of Surgery, Indian Veterinary Research Institute-Izatnagar, Bareilly, India
Abhijit M. Pawde ; Division of Surgery, Indian Veterinary Research Institute-Izatnagar, Bareilly, India
Karam P. Singh ; Division of Pathology, Indian Veterinary Research Institute-Izatnagar, Bareilly, India
Mudasir B. Gugjoo ; Division of Surgery, Indian Veterinary Research Institute-Izatnagar, Bareilly, India
Dr. Amarpal orcid id orcid.org/0000-0002-4827-3433 ; Division of Surgery, Indian Veterinary Research Institute-Izatnagar, Bareilly, India

Puni tekst: engleski pdf 360 Kb

str. 189-200

preuzimanja: 668

citiraj

Sažetak

The present study was conducted on 16 New Zealand White rabbits of 10-12 months of age, to evaluate the healing potential of earthworm coelomic fluid in full thickness skin wounds. Under xylazine-ketamine anaesthesia, four rectangular full thickness excisional skin wounds, measuring 2×2 cm2 were created on the dorsum of each animal and designated as groups I, II, III and IV. Wounds were treated by topical coelomic fluid (I), 0.5 % povidone-iodine and coelomic fluid (II), 0.5 % povidone-iodine (III) and normal saline (IV). Healing was evaluated on the basis of gross and histomorphological parameters. The mean wound area was significantly lesser (P<0.05) in the wounds of groups I and II as compared to groups III and IV, up to 21 days. Out of 16 wounds, nine wounds in group I (56.25 %) and 11 wounds in group II (68.75 %) healed completely by day 21, but none in groups III and IV. Histomorphological studies showed more mature and densely placed collagen and better epithelialization in groups I and II as compared to groups III and IV. It was concluded that coelomic fluid of the earthworm Eisenia foetida can accelerate healing of full-thickness skin wounds in rabbits.

Ključne riječi

earthworm; coelomic fluid; skin; wounds; rabbits

Hrčak ID:

138460

URI

https://hrcak.srce.hr/138460

Datum izdavanja:

27.5.2015.

Podaci na drugim jezicima: hrvatski

Posjeta: 1.385 *