Izvorni znanstveni članak
Cell Apoptosis as Assessed by M30 Expression in Keratoacanthoma and Squamous Cell Carcinoma
Tanja Batinac
Gordana Zamolo
Gordana Brumini
Darko Biljan
Duška Petranović
Biserka Trošelj-Vukić
Sažetak
Involution displayed by keratoacanthoma (KA) represents an important difference between KA and squamous cell
carcinoma (SCC). It has been suggested that apoptosis plays a part in process of involution of KA. Altogether 150 specimens
were included in this study, 30 cases of each; normal skin (NS), proliferative (pKA) and regressing keratoacanthoma
(rKA), well differentiated (wdSCC) and poorly differentiated (pdSCC) squamous cell carcinoma. All samples were
examined immunohistochemicaly for expression of M30 protein. A significantly lower number of M30 positive cells has
been detected in NS as compared to skin tumors examined (p<0.001), except for rKA (p=0.057). The highest percentage
of M30 positive cells was detected in pdSCC (p<0.001) as compared with all other examined groups. Keratinocytes of
normal and changed epidermis expressing higher levels of M30 protein were predominately found in sun-exposed areas
(c
2=14.93; p=0.060). There was an increasing trend of M30 protein expression with increasing age of the patient in NS
and skin tumors examined. Majority of skin tumors with higher percentage of M30 positive cells tended to display higher
Ki-67 expression. M30 expression was highly correlated with bak (r=0.811; p=0.048) and granzyme B expression in rKA
(r=0.733; p=0.015). Cell apoptosis as assessed by M30 expression is, generally, increased in examined skin tumors and
related to cell proliferation. Cell apoptosis mediated by bak and granzyme B expression could contribute to KA regression.
Ključne riječi
apoptosis; keratoacanthoma; M30; squamous cell carcinoma
Hrčak ID:
27217
URI
Datum izdavanja:
7.7.2008.
Posjeta: 1.240 *