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Urates in exhaled breath condensate of children with obstructive sleep apnea

Vukmir Vlasic ; Women’s & Children’s Hospital, Pediatric Pulmonology, Lafayette, LA, USA
Jasenka Trifunovic ; Odjel za kliničku biokemiju Kliničkog bolničkog centra Osijek
Ivana Cepelak ; Zavod za medicinsku biokemiju i hematologiju, Farmaceutsko-biokemijski fakultet Sveučilišta u Zagrebu
Petra Nimac ; Dječja bolnica Srebrnjak, Zagreb
Renata Zrinski Topic ; Klinički zavod za laboratorijsku dijagnostiku Dječje bolnice Srebrnjak, Zagreb
Slavica Dodig orcid.org/0000-0002-3419-5171 ; Klinički zavod za laboratorijsku dijagnostiku Dječje bolnice Srebrnjak, Zagreb

Sažetak

Background: Urate levels may be a marker of oxidative stress. The aim of the present study was to find out are there any differences in urate concentrations in exhaled breath condensate (EBC) between children with obstructive sleep apnea (OSA) and healthy children.
Materials and methods: EBC was collected in children with obstructive sleep apnea (OSA) and clinically healthy children. Urate measurements in EBC and serum were performed by enzymatic co-lor test.
Results: The higher concentration of urates in EBC of children with OSA than clinically healthy chil-dren indicate the oxidative stress in their airways. Since there was no significant difference in serum concentration of urates between children with OSA and healthy children, it could be considered that urates are sintetized in the airways of children with OSA.
Conclusions: The present study indicated that urates in EBC (but not in serum) may be used as a marker of local synthesis of antioxidant compounds, but definitive conclusion must be supported by investigations involving larger number of participants.

Ključne riječi

exhaled breath condensate; obstructive sleep apnea; oxidative stress; urates

Hrčak ID:

69657

URI

https://hrcak.srce.hr/69657

Datum izdavanja:

15.6.2011.

Posjeta: 1.746 *