Izvorni znanstveni članak
Risk factors for fatal outcome in patients with opioid dependence treated with methadone in a family medicine setting in Croatia
Venija Cerovečki
; Department for Family Medicine, University of Zagreb, School of Medicine, Zagreb, Croatia
Hrvoje Tiljak
; Department for Family Medicine, University of Zagreb, School of Medicine, Zagreb, Croatia
Zlata Ožvačić Adžić
; Department for Family Medicine, University of Zagreb, School of Medicine, Zagreb, Croatia
Miljenko Križmarić
; University of Maribor, Faculty of Medicine, Maribor, Slovenia
Peter Pregelj
; University Psychiatric Hospital Ljubljana, Ljubljana Polje, Slovenia
Andrej Kastelic
; University Psychiatric Hospital Ljubljana, Center for Treatment of Drug Addiction, Ljubljana, Slovenia
Sažetak
Aim To determine the risk factors for fatal outcome in patients
with opioid dependence treated with methadone at
the primary care level.
Methods A group of 287 patients with opioid dependence
was monitored prospectively from 1995 to 2007. At
the beginning of the study, we collected the data on patient
baseline characteristics, treatment characteristics, and
living environment. At the annual check-up, we collected
the data on daily methadone dose, method of methadone
therapy administration, and family physician’s assessment
of the patient’s drug use status.
Results Out of 287 patients, 8% died. Logistic regression
analysis showed that the predictors of fatal outcome were
continuation of drug use during previous therapeutic attempts
(odds ratio [OR], 19.402; 95% confidence interval
[CI], 1.659-226.873), maintenance therapy as the planned
treatment modality (OR, 3.738; 95% CI, 1.045-13.370), living
in an unstable relationship (OR, 9.275; 95% CI, 2.207-
38.984), and loss of continuity of care (OR, 12.643; 95% CI,
3.001-53.253).
Conclusion The patients presenting these risk factors require
special attention. It is important for family physicians
to insist on compliance with the treatment protocol and
intervene when they lose contact with the patient to prevent
the fatal outcome.
Ključne riječi
Hrčak ID:
102795
URI
Datum izdavanja:
15.2.2013.
Posjeta: 975 *