Kratko priopćenje

https://doi.org/10.2478/acph-2013-0035

In vitro dissolution and in vivo gamma-scintigraphic evaluation of press-coated salbutamol sulfate tablet

WEI LI ; Shenyang Pharmaceutical University, Shenyang 110016, Liaoning Province, China
CAI-HONG SHI ; Shenyang Pharmaceutical University, Shenyang 110016, Liaoning Province, China
YI-LING SHENG ; Shenyang Pharmaceutical University, Shenyang 110016, Liaoning Province, China
PING CUI ; The First Hospital of China Medical University, Shenyang 110001, Liaoning Province, China
YU-QING ZHAO ; Shenyang Pharmaceutical University, Shenyang 110016, Liaoning Province, China
XIANG-RONG ZHANG ; Shenyang Pharmaceutical University, Shenyang 110016, Liaoning Province, China

Sažetak

The aim of this study was to investigate the in vitro and in vivo performance of salbutamol sulfate press-coated tablets for delayed release. The in vitro release behavior of press-coated tablets with the outer layer of PEG 6000/Eudragit S100 blends (2:1) in pH 1.2 (0.1 mol L–1 HCl) and then pH 6.8 buffer solution was examined. Morphological change of the press-coated tablet during in vitro release was recorded with a digital camera. Release of salbutamol sulfate from press-coated tablets was less than 5 % before 3 h and was completed after 8 h in pH 6.8 phosphate buffer solution. In vivo gamma scintigraphy study carried out on healthy men indicated that the designed system released the drug in lower parts of the GI tract after a lag time of 5 hours. The results showed the capability of the system of achieving delayed release of the drug in both in vitro and in vivo gamma scintigraphy studies.

Ključne riječi

salbutamol sulfate; press-coated tablet; PEG 6000-Eudragit S100 blends; dissolution; gamma scintigraphy

Hrčak ID:

110462

URI

https://hrcak.srce.hr/110462

Datum izdavanja:

31.12.2013.

Posjeta: 1.039 *