Acta Pharmaceutica, Vol. 65 No. 1, 2015.
Kratko priopćenje
https://doi.org/10.1515/acph-2015-0004
Effect of 1-(phenyl)-N’-(4-methoxybenzylidene)-9H-pyrido[3,4-b]indole-3-carbohydrazide on in vitropoliovirus replication
PATRICIA R. SANTOS
; Post-Graduate Program in Pharmaceutical Sciences, State University of Maringá, 87020-900, Maringá, PR, Brazil
ANELISE S. NAZARI FORMAGIO
BENEDITO PRADO DIAS FILHO
CELSO VATARU NAKAMURA
MARIA HELENA SARRAGIOTTO
TANIA UEDA-NAKAMURA
Sažetak
The effect of the alkaloid, 1-(phenyl)-N’-(4-methoxybenzylidene)-9H-pyrido[3,4-b]indole-3-carbohydrazide (PMC)on poliovirus (PV) replication cycle in Vero cells was assayed by inhibition of the cytopathic effect (CPE) and inhibition of plaque forming units (PFU). Both methodologies suggested that the mode of action was avoidance of infection progression in the host cell. The compound was able to prevent CPE and PFU formation when the cells were pretreated with PMC for 24 h prior to PV infection. In addition, when the alkaloid was continuously maintained in the infected cultures, the spread of PV to adjacent cells was impaired. The pre-exposure and post-exposure prophylactic applications are possible situations in which an anti-PV drug might be used. Future studies are needed to elucidate the PMC mode of action and verify the feasibility of PMC use of in vivo. No antipicornavirus agent is currently approved for clinical use.
Ključne riječi
1-(phenyl)-N’-(4-methoxybenzylidene)-9H-pyrido[3,4-b]indole-3-carbohydrazide; beta-carboline; poliovirus; antiviral activity
Hrčak ID:
128391
URI
Datum izdavanja:
31.3.2015.
Posjeta: 1.240 *