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https://doi.org/10.1515/acph-2015-0007

Effect of oral administration of green tea extract in various dosage schemes on oxidative stress status of mice in vivo

HANA BÁRTÍKOVÁ ; Faculty of Pharmacy, Charles University in Prague, CZ-500 05 Hradec Králové, Czech Republic
LENKA SKÁLOVÁ ; Faculty of Pharmacy, Charles University in Prague, CZ-500 05 Hradec Králové, Czech Republic
KATEŘINA VALENTOVÁ ; Faculty of Medicine and Dentistry, Palacký University, CZ-775 15 Olomouc, Czech Republic
PETRA MATOUŠKOVÁ ; Faculty of Pharmacy, Charles University in Prague, CZ-500 05 Hradec Králové, Czech Republic
BARBORA SZOTÁKOVÁ ; Faculty of Pharmacy, Charles University in Prague, CZ-500 05 Hradec Králové, Czech Republic
JAN MARTIN ; Faculty of Pharmacy, Charles University in Prague, CZ-500 05 Hradec Králové, Czech Republic
VOJTĚCH KVITA ; Faculty of Pharmacy, Charles University in Prague, CZ-500 05 Hradec Králové, Czech Republic
IVA BOUŠOVÁ ; Faculty of Pharmacy, Charles University in Prague, CZ-500 05 Hradec Králové, Czech Republic

Sažetak

Green tea is a favorite beverage and its extracts are popular components of dietary supplements. The aim of the present in vivo study was to obtain detailed information about the effect of a standard green tea extract (Polyphenon, P), at different doses, on antioxidant enzymes and oxidative stress markers in murine blood, liver, small and large intestine. In all doses, P improved the oxidative stress status via an increased content of plasmatic SH-groups (by 21–67 %). Regarding antioxidant enzymes in tissues, the low dose of P had the best effect as it elevated the activity of NADPH/quinone reductase in liver and small intestine, thioredoxin reductase in small intestine and hepatic superoxide dismutase. Based on these facts, consumation of green tea seems to be safe and beneficial, while consumption of dietary supplements containing high doses of catechins may disturb oxidative balance by lowering the activity of thioredoxin reductase, glutathione S-transferase, glutathione reductase and superoxide dismutase.

Ključne riječi

green tea extract; flavonoids; green tea catechins; antioxidant enzymes

Hrčak ID:

128611

URI

https://hrcak.srce.hr/128611

Datum izdavanja:

31.3.2015.

Posjeta: 1.524 *