Acta Pharmaceutica, Vol. 66 No. 4, 2016.
Izvorni znanstveni članak
https://doi.org/10.1515/acph-2016-0041
A dual strategy to improve psychotic patients' compliance using sustained release quetiapine oral disintegrating tablets
AHMED REFAAT
; Pharmaceutics Department, Faculty of Pharmacy, Alexandria University, Alexandria, Egypt
MAGDA SOKAR
; Pharmaceutics Department, Faculty of Pharmacy, Alexandria University, Alexandria, Egypt
FATMA ISMAIL
; Pharmaceutics Department, Faculty of Pharmacy, Alexandria University, Alexandria, Egypt
NABILA BORAEI
; Pharmaceutics Department, Faculty of Pharmacy, Alexandria University, Alexandria, Egypt
Sažetak
Quetiapine (QT) is a short acting atypical antipsychotic drug effective in schizophrenia and bipolar disorder. This study aims at designing a novel dosage form of sustained release taste-masked QT orally disintegrating tablets (ODTs) based on solid lipid micro-pellets (SLMPs). QT SLMPs were prepared using the hot melt extrusion technique utilizing three lipid carriers: Compritol, Precirol and white beeswax either alone or in mixtures. They showed sustained QT release and a taste masking effect. The selected QT SLMP was further blended with an aqueous solution containing polyvinylpyrollidone (2.5%), croscarmellose sodium (2%) and mannitol (50%); it was then lyophilized into ODT in a mass ratio of 1:2 respectively. ODTs containing QT SLMPs showed: average wetting time (40.92 s), average oral disintegration time (21.49 s), average hardness (16.85 N) and also imparted suitable viscosity to suspend pellets during lyophilization process. In conclusion, lyophilization is a promising technique for the formulation of multiparticulate systems into ODTs.
Ključne riječi
solid lipid micro pellets; multiparticulate; quetapine, orally disintegrating tablets
Hrčak ID:
161199
URI
Datum izdavanja:
31.12.2016.
Posjeta: 1.318 *