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Acta Pharmaceutica, Vol.67 No.2 Lipanj 2017.

Kratko priopćenje
DOI: 10.1515/acph-2017-0012

The bioguided fractionation and pharmacological activity of an endemic Salix canariensis species

SANDRA DÉVORA GUTIÉRREZ   ORCID icon orcid.org/0000-0002-7490-0357 ; Unidad de Farmacología y Farmacognosia, Sección de Farmacia, Facultad de Ciencias de La Salud, Universidad de La Laguna, 38071, La Laguna, Tenerife, Canary Islands, Spain
SUSANA ABDALA KURI ; Unidad de Farmacología y Farmacognosia, Sección de Farmacia, Facultad de Ciencias de La Salud, Universidad de La Laguna, 38071, La Laguna, Tenerife, Canary Islands, Spain
DOMINGO MARTÍN-HERRERA ; Unidad de Farmacología y Farmacognosia, Sección de Farmacia, Facultad de Ciencias de La Salud, Universidad de La Laguna, 38071, La Laguna, Tenerife, Canary Islands, Spain

Puni tekst: engleski, pdf (562 KB) str. 265-273 preuzimanja: 18* citiraj
APA
GUTIÉRREZ, S.D., KURI, S.A., MARTÍN-HERRERA, D. (2017). The bioguided fractionation and pharmacological activity of an endemic Salix canariensis species. Acta Pharmaceutica, 67(2). doi:10.1515/acph-2017-0012

Sažetak
The present study was designed to confirm the wide traditional use of treating pain with Salix canariensis, an endemic species of the Macaronesian region. The active compounds were identified. Pharmacological activities were explored in experimental animals by acetic acid-induced writhing, formalin and Levy´s tests, and bioactive compounds were identified after a bio-guided fractionation of the most active organic extract. S. canariensis extract, orally administrated at different doses, led to a significant reduction in writhing, caused a moderate decrease of formalin-induced pain and revealed an excellent dose-dependent anti-inflammatory effect. Bioassay-guided fractionation of the ethyl acetate extract suggested the possible presence of pentacyclic triterpenes from oleanane and ursane series. These findings allow the conclusion that S. canariensis exerts analgesic and anti-inflammatory activities, documenting its traditional use in the treatment of pain and inflammatory diseases.

Ključne riječi
Salix canariensis; analgesic activity; anti-inflammatory activity; bioassay fractionation; pentacyclic triterpenes; ursanes; oleananes

Hrčak ID: 172755

URI
http://hrcak.srce.hr/172755

Posjeta: 39 *