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Acta Pharmaceutica, Vol.67 No.2 Lipanj 2017.

Izvorni znanstveni članak
https://doi.org/10.1515/acph-2017-0020

Biomimetic insulin-imprinted polymer nanoparticles as a potential oral drug delivery system

PIJUSH KUMAR PAUL ; Molecular Recognition Materials Research Unit, Nanotec-PSU Center of Excellence on Drug Delivery System, Department of Pharmaceutical Chemistry, Faculty of Pharmaceutical Sciences, Prince of Songkla University, Hatyai, Songkhla 90112, Thailand
ALONGKOT TREETONG ; National Nanotechnology Center (NANOTEC), National Science and Technology Development Agency (NSTDA), Thailand Science Park, Phahonyothin Road, Pathum Thani 12120, Thailand
ROONGNAPA SUEDEE ; Molecular Recognition Materials Research Unit, Nanotec-PSU Center of Excellence on Drug Delivery System, Department of Pharmaceutical Chemistry, Faculty of Pharmaceutical Sciences, Prince of Songkla University, Hatyai, Songkhla 90112, Thailand

Puni tekst: engleski, pdf (2 MB) str. 149-168 preuzimanja: 112* citiraj
APA
PAUL, P.K., TREETONG, A., SUEDEE, R. (2017). Biomimetic insulin-imprinted polymer nanoparticles as a potential oral drug delivery system. Acta Pharmaceutica, 67(2). doi:10.1515/acph-2017-0020

Sažetak
In this study, we investigate molecularly imprinted polymers (MIPs), which form a three-dimensional image of the region at and around the active binding sites of pharmaceutically active insulin or are analogous to  cells bound to insulin. This approach was employed to create a well-defined structure within the nanospace cavities that make up functional monomers by cross-linking. The obtained MIPs exhibited a high adsorption capacity for the target insulin, which showed a significantly higher release of insulin in solution at pH 7.4 than at pH 1.2. In vivo studies on diabetic Wistar rats showed that the fast onset within 2 h is similar to subcutaneous injection with a maximum at 4 h, giving an engaged function responsible for the duration of glucose reduction for up to 24 h. These MIPs, prepared as nanosized material, may open a new horizon for oral insulin delivery.

Ključne riječi
molecularly imprinted polymers; insulin; nanoparticles; islet cells; oral drug delivery

Hrčak ID: 176893

URI
http://hrcak.srce.hr/176893

Posjeta: 202 *