Izvorni znanstveni članak
https://doi.org/10.2478/10004-1254-60-2009-1901
Prostate-Specific Antigen (PSA) in Serum in Relation to Blood Lead Concentration and Alcohol Consumption in Men
Alica Pizent
orcid.org/0000-0003-0216-0166
; Institute for Medical Research and Occupational Health, Zagreb, Croatia
Božo Čolak
; University Clinic for Diabetes, Endocrinologyand Metabolic Diseases “Vuk Vrhovac”, Zagreb, Croatia
Zorana Kljaković Gašpić
; Institute for Medical Research and Occupational Health, Zagreb, Croatia
Spomenka Telišman
; Institute for Medical Research and Occupational Health, Zagreb, Croatia
Sažetak
The combined infl uence of age, smoking, alcohol, blood lead and cadmium concentrations, and serum copper, zinc, and selenium concentrations on prostate-specifi c antigen (PSA) in serum was investigated in a group of 57 men aged 21 years to 40 years. The subjects had no occupational exposure to metals and no other known reasons suspected of infl uencing prostate function or metal metabolism. No signifi cant correlation was found between PSA and any of the explanatory variables considered. Nevertheless, when taking into account all of the above-mentioned potentially explanatory variables, the results of stepwise multiple regression showed a signifi cant increase in PSA with respect to an increase in blood lead, and a decrease in PSA with respect to an increase in intensity of alcohol consumption. The median and range values of blood lead concentration in the 57 men were 26.0 µg L-1 and (10.1 to 108.0) µg L-1, respectively. These results suggest that even a low-level environmental lead exposure, common for general populations worldwide, may contribute to the risk of prostate cancer in men. The infl uence of lead as well as cadmium, zinc, and selenium on prostate damage and PSA should be further investigated in relatively young men for the purpose of disease prevention.
Ključne riječi
cadmium exposure; human environmental lead exposure; lifestyle factors; prostate damage; toxic and essential metals interaction
Hrčak ID:
34856
URI
Datum izdavanja:
27.3.2009.
Posjeta: 2.260 *