Izvorni znanstveni članak
Association of Nephrolithiasis and Gene for Glucose Transporter Type 9 (SLC2A9): Study of 145 Patients
Ozren Polašek
; Andrija Štampar School of Public Health, University of Zagreb Medical School, Zagreb, Croatia
Grgo Gunjača
; Univerisity of Split Medical School, Split, Croatia
Ivana Kolčić
; Andrija Štampar School of Public Health, University of Zagreb Medical School, Zagreb, Croatia
Lina Zgaga
; Andrija Štampar School of Public Health, University of Zagreb Medical School, Zagreb, Croatia
Snježana Džijan
; University of Osijek Medical School, Osijek, Croatia
Robert Smolić
; University of Osijek Medical School, Osijek, Croatia
Martina Smolić
; University of Osijek Medical School, Osijek, Croatia
Jasminka Milas-Ahić
; University of Osijek Medical School, Osijek, Croatia
Vatroslav Šerić
; University of Osijek Medical School, Osijek, Croatia
Josip Galić
; University of Osijek Medical School, Osijek, Croatia
Sandra Tucak-Zorić
; University of Osijek Medical School, Osijek, Croatia
Antun Tucak
; University of Osijek Medical School, Osijek, Croatia
Igor Rudan
; Croatian Centre for Global Health, University of Split Medical School, Split, Croatia
Gordan Lauc
; Faculty of Pharmacy and Biochemistry, University of Zagreb, Zagreb, Croatia
Sažetak
Aim To investigate the association of nephrolithiasis and
solute carrier family 2, facilitated glucose transporter,
member 9 (SLC2A9), also known as glucose transporter
type 9, Glut9.
Methods A total of 145 participants were recruited in the
period April-October 2008 from the Department of Mineral
Research of the Medical School Osijek, Osijek, Croatia; 58
(40%) had confirmed nephrolithiasis and 87 (60%) were asymptomatic.
Four single nucleotide polymorphisms (SNP)
from the SLC2A9 gene were genotyped in both groups
(rs733175, rs6449213, rs1014290, and rs737267).
Results There was a weak but significant association of all
4 SNPs and nephrolithiasis (P = 0.029 for rs733175; P = 0.006
for rs6449213; P = 0.020 for rs1014290, and P = 0.011 for
rs737267). Logistic regression in an age- and sex-adjusted
model suggested that genotype C/T for rs6449213 had
odds ratio for nephrolithiasis of 2.89 (95% confidence interval
1.13-7.40). This SNP explained a total of 4.4% of nephrolithiasis
variance.
Conclusion Development of nephrolithiasis may be associated
with SLC2A9 gene. Further studies are needed to
clarify the role of SLC2A9 gene as a link between uric acid
and nephrolithiasis.
Ključne riječi
SLC2A9; GLUT9; nephrolithiasis; uric acid; gout
Hrčak ID:
53506
URI
Datum izdavanja:
15.2.2010.
Posjeta: 1.217 *