Izvorni znanstveni članak
Human Brucellosis in Macedonia – 10 Years of Clinical Experience in Endemic Region
Mile Bosilkovski
orcid.org/0000-0003-0182-4741
; University Clinic for Infectious Diseases and Febrile Conditions, Skopje, Republic of Macedonia
Ljiljana Krteva
; University Clinic for Infectious Diseases and Febrile Conditions, Skopje, Republic of Macedonia
Marija Dimzova
; University Clinic for Infectious Diseases and Febrile Conditions, Skopje, Republic of Macedonia
Ivan Vidinic
; University Clinic for Infectious Diseases and Febrile Conditions, Skopje, Republic of Macedonia
Zaklina Sopova
; University Clinic for Infectious Diseases and Febrile Conditions, Skopje, Republic of Macedonia
Katerina Spasovska
; University Clinic for Infectious Diseases and Febrile Conditions, Skopje, Republic of Macedonia
Sažetak
Aim To present our 10-year clinical experience with brucellosis
patients at the University Clinic for Infectious Diseases
and Febrile Conditions in Skopje, Republic of Macedonia.
Methods A total of 550 patients with brucellosis treated
between 1998 and 2007 were retrospectively assessed for
their demographic, epidemiological, and clinical characteristics
and outcomes.
Results Of the 550 patients, 395 (72%) were male. The median
age was 34.5 years (range, 1-82). Direct contact with
infected animals was recorded in 333 (61%) patients and
positive family history in 310 (56%). The most frequently
seen symptoms were arthralgia (438, 80%), fever (419,
76%), and sweating (394, 72%). The most common signs
were fever and hepatomegaly, which were verified in 357
(65%) and 273 (50%) patients, respectively. Focal brucellosis
was found in 362 patients (66%) and osteoarticular in
299 (54%). Therapeutic failures were registered in 37 (6.7%)
patients. Of the 453 (82%) patients who completed a follow-
up period of at least 6 months, relapses occurred in
60 (13%).
Conclusion Due to non-specific clinical manifestation
and laboratory parameters, brucellosis should be considered
one of the differential diagnoses of any patient suffering
from obscure involvement of various organs in a brucellosis-
endemic region. High percentage of relapses and
therapeutic failures in spite of the use of currently recommended
therapeutic regimens indicates the seriousness of
this zoonosis and the need to control it.
Ključne riječi
brucellosis; signs and symptoms; diagnosis; serologic tests; treatment outcome
Hrčak ID:
58586
URI
Datum izdavanja:
15.8.2010.
Posjeta: 1.991 *