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Original scientific paper

Liposomal gel with chloramphenicol: Characterisation and in vitro release

ŽELJKA PAVELIĆ
NATASA ŠKALKO-BASNET
IVAN JALŠENJAK

Fulltext: english, pdf (117 KB) pages 319-330 downloads: 1.167* cite
APA 6th Edition
PAVELIĆ, Ž., ŠKALKO-BASNET, N. & JALŠENJAK, I. (2004). Liposomal gel with chloramphenicol: Characterisation and in vitro release. Acta Pharmaceutica, 54 (4), 319-330. Retrieved from https://hrcak.srce.hr/16907
MLA 8th Edition
PAVELIĆ, ŽELJKA, et al. "Liposomal gel with chloramphenicol: Characterisation and in vitro release." Acta Pharmaceutica, vol. 54, no. 4, 2004, pp. 319-330. https://hrcak.srce.hr/16907. Accessed 19 Aug. 2019.
Chicago 17th Edition
PAVELIĆ, ŽELJKA, NATASA ŠKALKO-BASNET and IVAN JALŠENJAK. "Liposomal gel with chloramphenicol: Characterisation and in vitro release." Acta Pharmaceutica 54, no. 4 (2004): 319-330. https://hrcak.srce.hr/16907
Harvard
PAVELIĆ, Ž., ŠKALKO-BASNET, N., and JALŠENJAK, I. (2004). 'Liposomal gel with chloramphenicol: Characterisation and in vitro release', Acta Pharmaceutica, 54(4), pp. 319-330. Available at: https://hrcak.srce.hr/16907 (Accessed 19 August 2019)
Vancouver
PAVELIĆ Ž, ŠKALKO-BASNET N, JALŠENJAK I. Liposomal gel with chloramphenicol: Characterisation and in vitro release. Acta Pharm. [Internet]. 2004 [cited 2019 August 19];54(4):319-330. Available from: https://hrcak.srce.hr/16907
IEEE
Ž. PAVELIĆ, N. ŠKALKO-BASNET and I. JALŠENJAK, "Liposomal gel with chloramphenicol: Characterisation and in vitro release", Acta Pharmaceutica, vol.54, no. 4, pp. 319-330, 2004. [Online]. Available: https://hrcak.srce.hr/16907. [Accessed: 19 August 2019]

Abstracts
The aim of our study was to develop a liposomal carrier system for the local treatment of bacterial vaginosis, capable to efficiently deliver entrapped drug during an extended period of time. Chloramphenicol was entrapped in liposomes composed of egg phosphatidylcholine/egg phosphatidylgycerol-sodium (9:1, molar ratio) and prepared by two different methods, the proliposome method and the polyol dilution method. Both liposome preparations were characterised and compared for particle size, polydispersity, entrapment efficiency and tested for in vitro stability in media that simulate human vaginal conditions (buffer pH 4.5 and vaginal fluid simulant). To achieve application viscosity of liposomes and to further improve their stability, liposomes prepared by the proliposome method were incorporated in the bioadhesive gel made of Carbopol 974P NF resin. In vitro release studies of liposomes incorporated in the gel have shown a prolonged release of entrapped chloramphenicol compared to control gel. Even after 24 hours of incubation in the vaginal fluid simulant, more than 40% of the originally entrapped drug was still retained in the gel. Storage stability studies have proven the ability of the Carbopol 974P NF gel to preserve the original size distribution of incorporated liposomes. All the performed experiments confirm the applicability of liposomes as a novel drug carrier system for the local treatment of bacterial vaginosis.

Keywords
liposomes; chloramphenicol; bioadhesive gel; stability; vaginal application

Hrčak ID: 16907

URI
https://hrcak.srce.hr/16907

[croatian]

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