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Review article

Nutrigenetics and colon cancer

MLADEN MLADEN JOKIĆ ; Division of Molecular Medicine, Laboratory of Personalized Medicine, Ruđer Bošković Institute, Bijenička c. 54, 10000 Zagreb, Croatia
SANJA KAPITANOVIĆ ; Division of Molecular Medicine Laboratory of Personalized Medicine, Ruđer Bošković Institute, Bijenička c. 54, 10000 Zagreb, Croatia

Fulltext: english, pdf (2 MB) pages 51-54 downloads: 890* cite
APA 6th Edition
MLADEN JOKIĆ, M. & KAPITANOVIĆ, S. (2009). Nutrigenetics and colon cancer. Periodicum biologorum, 111 (1), 51-54. Retrieved from https://hrcak.srce.hr/35994
MLA 8th Edition
MLADEN JOKIĆ, MLADEN and SANJA KAPITANOVIĆ. "Nutrigenetics and colon cancer." Periodicum biologorum, vol. 111, no. 1, 2009, pp. 51-54. https://hrcak.srce.hr/35994. Accessed 19 Sep. 2021.
Chicago 17th Edition
MLADEN JOKIĆ, MLADEN and SANJA KAPITANOVIĆ. "Nutrigenetics and colon cancer." Periodicum biologorum 111, no. 1 (2009): 51-54. https://hrcak.srce.hr/35994
Harvard
MLADEN JOKIĆ, M., and KAPITANOVIĆ, S. (2009). 'Nutrigenetics and colon cancer', Periodicum biologorum, 111(1), pp. 51-54. Available at: https://hrcak.srce.hr/35994 (Accessed 19 September 2021)
Vancouver
MLADEN JOKIĆ M, KAPITANOVIĆ S. Nutrigenetics and colon cancer. Periodicum biologorum [Internet]. 2009 [cited 2021 September 19];111(1):51-54. Available from: https://hrcak.srce.hr/35994
IEEE
M. MLADEN JOKIĆ and S. KAPITANOVIĆ, "Nutrigenetics and colon cancer", Periodicum biologorum, vol.111, no. 1, pp. 51-54, 2009. [Online]. Available: https://hrcak.srce.hr/35994. [Accessed: 19 September 2021]

Abstracts
Colon cancer is the third most common type of cancer and the second
leading cause of cancer-related death in the western world. Many epidemiological studies have shown that lifestyle and intake of various food components influence the colon carcinogenesis. Novel concepts such as nutrigenomics and nutrigenetics which study the interaction between diet and genes with common goal to optimize health through personalization of diet, provide approaches to elucidate the complex relationship between nutrients and genetic polymorphisms involved in various diseases like colon cancer.
Nutrigenetics of colon cancer is based on correlation between folate metabolism and polymorphisms in the genes encoding crucial enzymes in folate metabolism pathway. The folate pathway influences abberant pyrimidine and purine synthesis as well as the global DNA hypomethylation and hypermethylation of tumor supressor genes such as APC, hMLH1, p16 and E-cadherin in colon cancer. In addition, polymorphisms in the MTHFR, TYMS, MTR, MTRR, RFC, DHFR and other genes involved in the folate pathway have been shown to influence colon carcinogenesis. The central role of the folate pathway in the cell has made it a target for a variety of chemotherapeutics. Polymorphisms in the genes encoding crucial enzymes in the folate pathway might have an important role in the pharmacogenetics and nutrigenetics of colon cancer.

Keywords
Nutrigenetics; folate; colon cancer; SNPs

Hrčak ID: 35994

URI
https://hrcak.srce.hr/35994

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