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Original scientific paper
https://doi.org/10.2478/10004-1254-60-2009-1974

Fumonisin B1 Neurotoxicity in Young Carp (Cyprinus carpio L.)

Sanja Kovačić ; Department of Neurology, General Hospital Zabok, Zabok, Croatia
Stjepan Pepeljnjak ; Department of Microbiology, School of Pharmacy and Biochemistry, University of Zagreb, Zagreb, Croatia
Zdravko Pertinec ; Department for Biology and Pathology of Fishes and Bees, School of Veterinary Medicine, University of Zagreb, Zagreb, Croatia
Maja Šegvić Klarić ; Department of Neurology, General Hospital Zabok, Zabok, Croatia

Fulltext: english, pdf (236 KB) pages 419-425 downloads: 651* cite
APA 6th Edition
Kovačić, S., Pepeljnjak, S., Pertinec, Z. & Šegvić Klarić, M. (2009). Fumonisin B1 Neurotoxicity in Young Carp (Cyprinus carpio L.). Arhiv za higijenu rada i toksikologiju, 60 (4), 419-425. https://doi.org/10.2478/10004-1254-60-2009-1974
MLA 8th Edition
Kovačić, Sanja, et al. "Fumonisin B1 Neurotoxicity in Young Carp (Cyprinus carpio L.)." Arhiv za higijenu rada i toksikologiju, vol. 60, no. 4, 2009, pp. 419-425. https://doi.org/10.2478/10004-1254-60-2009-1974. Accessed 19 Sep. 2020.
Chicago 17th Edition
Kovačić, Sanja, Stjepan Pepeljnjak, Zdravko Pertinec and Maja Šegvić Klarić. "Fumonisin B1 Neurotoxicity in Young Carp (Cyprinus carpio L.)." Arhiv za higijenu rada i toksikologiju 60, no. 4 (2009): 419-425. https://doi.org/10.2478/10004-1254-60-2009-1974
Harvard
Kovačić, S., et al. (2009). 'Fumonisin B1 Neurotoxicity in Young Carp (Cyprinus carpio L.)', Arhiv za higijenu rada i toksikologiju, 60(4), pp. 419-425. https://doi.org/10.2478/10004-1254-60-2009-1974
Vancouver
Kovačić S, Pepeljnjak S, Pertinec Z, Šegvić Klarić M. Fumonisin B1 Neurotoxicity in Young Carp (Cyprinus carpio L.). Arh Hig Rada Toksikol. [Internet]. 2009 [cited 2020 September 19];60(4):419-425. https://doi.org/10.2478/10004-1254-60-2009-1974
IEEE
S. Kovačić, S. Pepeljnjak, Z. Pertinec and M. Šegvić Klarić, "Fumonisin B1 Neurotoxicity in Young Carp (Cyprinus carpio L.)", Arhiv za higijenu rada i toksikologiju, vol.60, no. 4, pp. 419-425, 2009. [Online]. https://doi.org/10.2478/10004-1254-60-2009-1974

Abstracts
For years scientists have suspected that the environment plays a role in neurodegenerative diseases such as Alzheimer’s disease, Parkinson’s disease, and multiple sclerosis. Mycotoxin fumonisin B1 (FB1) is produced by several Fusarium species, mainly by Fusarium verticilioides, which is one of the most common fungi
associated with corn worldwide. Fumonisins are known to cause equine leukoencephalomalacia, a disease associated with the consumption of corn-bas d feeds contaminated with FB1. Here we have reported chronic experimental toxicosis in one-year-old carp (Cyprinus carpio L.) receiving feed containing 100 mg kg-1
or 10 mg kg-1 of added FB1 for 42 days. We focused on fumonisin toxicity in the fi sh brain. After staining with hemalaun-eosin, histology of the fi sh brain revealed vacuolated, degenerate, or necrotic neural cells, scattered around damaged blood capillaries and in the periventricular area. These fi ndings suggest that
fumonisin, although it is a hydrophilic molecule, permeated the blood-brain barrier of young carp and had a toxic effect on neuronal cells.

Keywords
blood-brain barrier; environment; mycotoxins; neurodegenerative diseases

Hrčak ID: 45374

URI
https://hrcak.srce.hr/45374

[croatian]

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