Izvorni znanstveni članak
Clinical Characteristics of Patients with Spondyloarthritides and HLA-B27 Positive Antigen
Marija Glasnović
Ivica Bošnjak
Miroslav Šram
Željko Vranješ
Aleksandar Včev
Blaženka Dobrošević
Jasminka Sinčić Petričević
Elizabeta Horvatić
Želimir Orkić
Refmir Tadžić
Anamarija Soldo
Dina Šišljagić
Kristijan Dinjar
Sažetak
The aim of this study was to present our experiences in diagnosing spondyloarthritides (SpA), and to list the most
common clinical features of HLA-B 27 positive patients.The study included 65 HLA-B 27 positive patients with confirmed
diagnosis of ankylosing spondylitis(AS) and psoriatic arthritis (PsA) who were analyzed between 2009 and 2010
in Clinic of Internal Medicine in Osijek. The diagnosis of seronegative spondyloarthritides was based on the ASAS (Assessment
in AS Working Group) classification criteria for axial and then supplemented with ASAS criteria for peripheral
SpA and was confirmed by radiological techniques. For diagnosing the ankylosing spondylitis (AS), there have been
applied the modified New York criteria. Radiological criteria for definite sacroiliitis according to the modified New York
criteria is bilateral sacroiliitis, grade 2–4 (2) or unilateral sacroiliitis, grade 3–4. For diagnosing the psoriatic arthritis
(PsA), there were used CASPAR diagnostic criteria. Other features of SpA are defined within the existing classification
criteria. HLA-B27 antigen was determined by direct immune-fluorescence technique using flow cytometer. The average
age of patients was 50.34 years, of whom 27 female (41.53%), 38 male (58.46%). Duration of illness was 15.79 years on
average.With 75.38% of patients, there had been determined the diagnosis of AS; 24.62% of patients had the diagnosis of
PsA. The most common clinical characteristics that patients had were: inflammatory back pain (pain Inflammation along
the lumbosacral spine), peripheral arthritis, intermittent pain in the gluteus, sacroiliitis, enthesitis, uveitis, dactilitis.
Ključne riječi
Spondyloarthtritides; HLA-B27; antigen; ASAS classification criteria
Hrčak ID:
68951
URI
Datum izdavanja:
24.6.2011.
Posjeta: 1.563 *